A Prospective Study of Histomorphological Spectrum of Biopsy Confirmed Skin Adenexal Tumors in a Tertiary Care Centre at Bikaner Region

Introduction: The adenexa are part of skin andcomprised of sebaceous glands, sweat glands and hairfollicles. Skin adenexal tumors are rare in occurrenceand precise classification of these neoplasms is difficult.Benign tumors are more common than malignanttumors. Current study aimed to know the histopathologyof skin adenexal neoplasm and to correlate with age,gender, loacation and type of differentiation.Material and methods: A prospective study of 57histopathologically confirmed cases of skin adenexaltumors was carried out in Department of Pathology. Inthis study biopsies were received in 10% formalin andstained by routine haematoxylin and eosin stain. Nonneoplastic conditions were excluded from the study.Results: Out of the 57 cases of skin adenexal tumorsstudied 55 (96.5% ) were benign and 2 (3.5% ) weremalignant with a male: female ratio of 1:1.3. The mostfrequent group of tumors were of eccrine/apocrineorigin 28/57 (49.1%) followed by follicular origin(38.6%) 22/57 and sebaceous origin 7/57 (12.9%).Pilomatrixoma was the most common benign tumorand sebaceous carcinoma was the only malignant tumorencountered in the study. Most common age groupaffected range from 41-60 years and mean age observedwas 45 years. Head and neck (47.5%, 27/57) was themost common site involved in both males and femaleswith a predominance in the facial region.Conclusion: Skin adenexal tumors (SAT) are very rareand the classification of these tumours is complex. Thesetumors are usually missed clinically and histopathologyproves to be the gold standard for diagnosis of theseneoplasms.

Evaluation of Bone Marrow Examination in Cases of Pancytopenia in Tertiary Health Center in North-West Rajasthan

Introduction: Pancytopenia is a very common consequenceof many haematological diseases with extensive differentialdiagnosis. It is described as the deficiency of all three cellularelements of blood resulting in anemia and leucopenia andthrombocytopenia. The severity and underlying pathologydetermines the management and prognosis. Bone marrowexamination is an effective way of evaluating various causesof pancytopenia along with other clinical, haematologicalfindings.Material and methods: In this prospective study, a total60 patients presenting with pancytopenia on initial work uprequiring bone marrow examination were studied along withtheir relevant clinical history, examination findings, routinehaematological findings.Results: Among 60 cases studied, age of patients ranged from1-85 years with slight male predominance. Most commonage group involve was 11-30 years. Most of the patientspresented with generalised weakness, pallor, fever. Dimorphicanemia was the predominant blood picture. The commonestmarrow finding was hypercellularity with megaloblasticerythropoiesis. The commonest cause of pancytopenia wasmegaloblastic anemia 62.79% followed by sub/aleukemicleukemia 25.57%.Conclusions: Bone marrow examination can diagnosedmajority of cases of pancytopenia along with comprehensiveclinical and haematological study. It is also helpful in planningfurther investigations and management.

Daily and seasonal activity patterns in blackheaded munia.

To test the circadian clock characteristics, activity behaviour of male blackheaded munia was recorded. Two experiments were performed. In experiment 1A, activity of munia was recorded under long days, LD (14L: 10D); and short days, SD (10L: 14D). Locomotor activity of two groups of munia exposed to equinox (12L: 12D) daylength followed by transfer of one group each to continuous dimlight (DD) and continuous bright light (LL) was recorded in experiment 1B. Experiment 2 aimed to describe seasonal trend in daily pattern of activity/rest cycle under natural illumination conditions (NDL). Hourly activity during daytime was more under SD than under LD. Munia did not exhibit bimodality in daily activity pattern; activity during morning, M (2h) was more than evening, E. A free-running activity rhythm was recorded in munia under DD; the same was arrhythmic under LL. The seasonal pattern in daily activity profiles under NDL corresponds to the seasonal changes in daylength. Daylength regulates daily and seasonal activity patterns in blackheaded munia.

Cardiovascular changes in thyroid disorder.

Thyroid hormones have a profound effect on the metabolism. The cardiovascular system is particularly sensitive to this metabolic alteration. Therefore it is not surprising that thyroid dysfunction can produce dramatic cardiovascular effects, often mimicking primary cardiac disease. Both hypothyroidsm and hyperthyroidsm produce a clinical syndrome causing a diagnostic and therapeutic dilemma to the endocrinologist and cardiologist. Furthermore, cardiac disease and amiodarone therapy can also produce thyroid abnormality.

Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: a short review.

The medicinal plants are widely used by the traditional medical practitioners for curing various diseases in their day to day practice. In traditional systems of medicine, different parts (leaves, stem, flower, root, seeds and even whole plant) of Ocimum sanctum Linn (known as Tulsi in Hindi), a small herb seen throughout India, have been recommended for the treatment of bronchitis, bronchial asthma, malaria, diarrhea, dysentery, skin diseases, arthritis, painful eye diseases, chronic fever, insect bite etc. The Ocimum sanctum L. has also been suggested to possess antifertility, anticancer, antidiabetic, antifungal, antimicrobial, hepatoprotective, cardioprotective, antiemetic, antispasmodic, analgesic, adaptogenic and diaphoretic actions. Eugenol (1-hydroxy-2-methoxy-4-allylbenzene), the active constituent present in Ocimum sanctum L., has been found to be largely responsible for the therapeutic potentials of Tulsi. Although because of its great therapeutic potentials and wide occurrence in India the practitioners of traditional systems of medicine have been using Ocimum sanctum L. for curing various ailments, a rational approach to this traditional medical practice with modern system of medicine is, however, not much available. In order to establish the therapeutic uses of Ocimum sanctum L. in modern medicine, in last few decades several Indian scientists and researchers have studied the pharmacological effects of steam distilled, petroleum ether and benzene extracts of various parts of Tulsi plant and eugenol on immune system, reproductive system, central nervous system, cardiovascular system, gastric system, urinary system and blood biochemistry and have described the therapeutic significance of Tulsi in management of various ailments. These pharmacological studies have established a scientific basis for therapeutic uses of this plant.