Taurine: A potential mediator for periodontal therapy

Taurine or 2-aminoethanesulfonic has many fundamental biological roles such as conjugation of bile acids, antioxidation, osmoregulation, membrane stabilization, and modulation of calcium signaling. It is essential for cardiovascular function and development and function of the skeletal muscle, the retina, and the central nervous system. Functions of taurine include osmoregulation; membrane stabilization; modulation of calcium levels; and antioxidation, antiapoptotic, anti-inflammatory, and antilipid activities. Taurine was first discovered as a component of ox (Bos taurus, from which its name is derived) bile in 1827; it had taken over a century before insights into its physiological functions were made. The present review throws light on the multifactorial properties of taurine and its potential to be used in periodontal therapy.

A Comparative Study of Management of Obsessive Compulsive Disorder: Pharmacotherapy Combined with Congnitive Behavior Therapy versus Pharmacotherapy alone.

Background : Obsessive compulsive disorder (OSD) is a disorder, debilitating in not just its chronic course, or prolonged and ussatisfactory treatment, but also in its clinical form. Serve socio-occupational impairment, poor health related quality of life, lack of understanding and support by the family and multiple co-morbidities complicate the scenario along with the slow and poor response to treatment, which emphasizes the need for developing more effectives ways of mannzinging these patients. Aim: To compare the effectiveness of Pharmacotherapy alone and when combined with Congnitive Behavior Therapy (CBT) in patients of OCD. Methods: 100 consecutive, first contact patients of either sex and between ages 16-40 years with active symptoms of OCD visiting the psychiatric OPD in sir Ganga Ram Hospial were recruited for the study. These were randomized into groups by draw of lots, after obtaining their informed conset. The subjects were assessed using semi-structire [erfpr,a cpveromg spcop-demographic and clinical characteristics of patient and his illeness and by using the following tools icd 10 criteria for ocd yale brown obsessive compulsive scale (YBOCS). Result: The combined therapy group and pharmacotheerapy only group had mena YBOCS scores of 31.24(S.D =3.613) scored at the end of the study were 21.89 S.D 2.768 and 23.09 ( S.D =3.272) in combin ed therapy 9.34 and 7.48 in combined therapy group and pharmacotherapy and group respactivelyl the change was statisfied significat with p value being < 0.01 Conculaton: The study revealed the superiority of combined treatment modality over pharmacotherapy alone in patient of OCD.