Study On Awareness, Acceptability & Clinical Outcome Of Post Partum - Iucd Insertion In A Tertiary Care Hospital Of North India

Background:Post partum period is ideal time for family planning counselling. Accessibility to health care facility is more during this period in our country. IUCD to prevent pregnancy is a highly effective, safe, long acting, coitus independent & reversible method of contraception with very low side effects.Objectives:This study was conducted to evaluate the awareness, acceptance, safety, efficacy, complications and expulsion rate of Post–partum Intrauterine Contraceptive Device (PP–IUCD) insertion among pregnant women in a tertiary care centre.Material and Methods: This was a prospective study was carried out in the department of Obstetrics and Gynaecology, Career Institute of Medical Sciences from November 2014 to October 2016 (ie.2years). Women delivering in the hospital and fulfilling inclusion criteria were included in the study after obtaining informed consent. The study protocol was approved by the ethics committee of the medical college. Results:Out of 1820 women, only 108 (5.9%) were aware about PP–IUCD and they received information from the IEC material displayed in the antenatal clinic. Out of these 108 women, 70 women (64.8%) agreed with PP–IUCD insertion. Out of 1712 unaware women, 930 (54.3%) agreed with PP–IUCD. Agreement with PP–IUCD insertion was higher in women who were aware about the PP–IUCD. Overall acceptability was found in 1000 (55%) patients. Out of the 1000 (55%) women who accepted the PP–IUCD insertion, only 573 (31.4%) women underwent PP–IUCD insertion. After PPIUCD insertion, 67.2% of women had an uneventful course and 32.8% women had complications. Not a single woman suffered from perforation, or any other life–threatening complication. Conclusion: The acceptance of PP–IUCD was high in present study and it is comparably more than other studies done globally. Awareness of PP–IUCD among these women was very poor despite high acceptance.The PP–IUCD was also demonstrably safe, having no reported incidence of perforation with low rates of expulsion, pelvic infection, and few lost strings.

Intrinsic Efficacy of Novel Poly-herbal Formulation Activity on Hypoglycemic, Immune Potentiating and Antioxidant Activities in Diabetic Individual.

Aims: The study was conducted to assess the synergistic poly-herbal formulation for diabetic patients to determine its three characteristics reducing excessive sugar level to normal, immune-potentiating and antioxidant. Study Design: Subjects were divided into four groups, Group I(NH), were normal healthy subjects, Group II(DI), were diabetics, group III (TTD) were tolbutamide treated diabetic patients, group IV(HFTD), were diabetic patients receiving combination herbal formulation in the, dosage of 5 g. /day for 4 weeks. Place of Study: Diabetic patients were contacted and convinced from two Government Hospitals-Hamidia Hospital, Bhopal and K. N. Katju hospital, Bhopal, (M.P.), India. Methodology: homogenous mixtures were obtained and encapsulated 500mg/per capsule. PMNL were isolated from blood and glucose level tests performed by autoanalyzer. Immune- potentiating activity was evaluated by different following methods like a ATPase sensitivity tests, cellular water content, cell, plasma membrane calcium content, Camp activity, Phaspholipase-C activity, contact angle measurement, NBT assay. Antioxidant activity evaluates by SOD and glutathione peroxidase methods. Results: Encouraging results prompt that, herbal formulation, which could be proved on excellent sugar level regulator. For efficient phagocytosis by PMNL such as membrane potential, cellular water content, calcium homeostatic, calcium messenger system, contact angle i.e. hydrophobicity measurement and finally particle internalization and Phagocytic index. result were exciting with herbal formulation since it was found to effective in correction of cell parameters related to phagocytosis and remarkable recovery in antioxidant enzymes in diabetic patients. Conclusion: In summary, the results obtained in the present investigation demonstrated\ that the present formulation beneficial in management of diabetic complication.

Visceral leishmaniasis: Experimental models for drug discovery.

Visceral leishmaniasis (VL) or kala-azar is a chronic protozoan infection in humans associated with significant global morbidity and mortality. The causative agent is a haemoflagellate protozoan Leishmania donovani, an obligate intracellular parasite that resides and multiplies within macrophages of the reticulo-endothelial system. Most of the existing anti-leishmanial drugs have serious side effects that limit their clinical application. As an alternate strategy, vaccination is also under experimental and clinical trials. The in vitro evaluation designed to facilitate rapid testing of a large number of drugs has been focussed on the promastigotes milt little attention on the clinically relevant parasite stage, amastigotes. Screening designed to closely reflect the situation in vivo is currently time consuming, laborious, and expensive, since it requires intracellular amastigotes and animal model. The ability to select transgenic Leishmania expressing reporter proteins, such as the green fluorescent proteins (GFP) or the luciferase opened up new possibilities for the development of drug screening models. Many experimental animal models like rodents, dogs and monkeys have been developed, each with specific features, but none accurately reproduces what happens in humans. Available in vitro and in vivo methodologies for antileishmanial drug screening and their respective advantages and disadvantages are reviewed.