Effect of HPMC and ethyl cellulose polymeric granules and its combinations in press coated tablets of lornoxicam: fabrication and in vitro characterization.

The main objective of the present exploration was to formulate and evaluate chronomodulated press-coated tablets to deliver the NSAID lornoxicam, when a pain in the joints, functional disability persist in the early morning time is typically observed in most Rheumatoid arthritis (RA) patients. Pre formulation studies and drug excipient compatibility studies were carried out for lornoxicam and excipients. Core tablets containing lornoxicam was prepared by direct compression method and the tablets were subjected to various pre-compression and post-compression parameters (C1-C4 formula) based on the above result best core tablet batch was selected and used for press coating processes. HPMC and EC granules were used as controlled release polymers in the outer layer. These tablets were subjected to pre and post compression parameters, finally the tablets were evaluated for lag time and in vitro dissolution. Results of preformulation studies were acceptable limits. No interaction was observed between lornoxicam and excipients by FTIR. The results of pre and post compression studies were within limits. Formulation code CC3 was identified as best formulation that extends a release profile with 6 h lag time followed by complete lornoxicam release after 8 h. From the graphical representation it can be well perceive that this is perfectly fit in to Korsemeyer which had a Regression coefficient (R2) of 0.9431. The results of the in-vitro release data of this layer were fitted to the Korsemeyer-Peppas equation to examine the release pattern of the drug from the polymeric system. The drug release was identified as super case II transport as the “n” value found to be more than 0.89.

Nonaqueous Enteric Coating Application of HPMC and Eudragit L100 on Hard Gelatin Capsules: Designed to Achieve Intestinal Delivery.

Omeprazole (OMZ) is a weak base proton pump inhibitor and it can be easily broken down in the acidic location before reaching to the small intestine where it is absorbed. Therefore, the main aim of this investigation is to protect the drug in the stomach environment with the object of exhibiting 100% drug release at the site of absorption. Prior to coating all the capsules were filled with API and other suitable excipients then placed on to the lab model conventional coating pan. Two different polymers such as (HPMC) and Eudragit L 100 were selected for this study. First, the pre coating solution (HPMC) was employed after drying enteric coating solution (Eudragit L 100) was applied under suitable coating parameter finally over coating solution of (HPMC) was applied and kept for drying. Different coating thickness ranges from 38.33 to 89.75% was observed by Scanning electron microscopy and tested for acid uptake test, disintegration and dissolution tests in pH 1.2 HCl media for 2 hours and pH 6.8 phosphate buffer solution. Less coating thickness capsules were allowed to penetrate the acid and the capsules were ruptured in an acid environment, therefore early drug release was occurred in acid media. Whereas capsules with high coating thickness of 89μm were not allowed acid to penetrate this indicates that the drug could be protected from degradation in the gastric environment.

Effect of HPMC and ethyl cellulose polymeric granules and its combinations in press coated tablets of lornoxicam: fabrication and in vitro characterization.

The main objective of the present exploration was to formulate and evaluate chronomodulated press-coated tablets to deliver the NSAID lornoxicam, when a pain in the joints, functional disability persist in the early morning time is typically observed in most Rheumatoid arthritis (RA) patients. Pre formulation studies and drug excipient compatibility studies were carried out for lornox-icam and excipients. Core tablets containing lornoxicam was prepared by direct compression method and the tablets were subjected to various pre-compression and post-compression parameters (C1-C4 formula) based on the above result best core tablet batch was selected and used for press coating processes. HPMC and EC granules were used as controlled release polymers in the outer layer. These tablets were subjected to pre and post compression parameters, finally the tablets were evaluated for lag time and in vitro dissolution. Results of preformulation studies were acceptable limits. No interaction was observed between lornoxicam and excipients by FTIR. The results of pre and post compression studies were within limits. Formulation code CC3 was identified as best formulation that extends a release profile with 6 h lag time followed by complete lornoxicam release after 8 h. From the graphical representation it can be well perceive that this is perfectly fit in to Korsemeyer which had a Regression coefficient (R2) of 0.9431. The results of the in-vitro release data of this layer were fitted to the Korsemeyer-Peppas equation to examine the release pattern of the drug from the polymeric system. The drug release was identified as super case II transport as the “n” value found to be more than 0.89.