ABSTRACT
Aims: The study aims to determine the efficacy and safety of moxifloxacin 0.5% eye drops versus tobramycin 0.3% eye dropsin pediatric population with purulent bacterial conjunctivitis.Study design: Prospective, randomized, investigator-masked, clinical study was conducted on patients.Place and Duration of Study: This study was conducted by the Department of Ophthalmology Veer Chandra Singh GarhwaliGovernment Medical College, Srinagar, Uttarakhand, between March 2018 and February 2019.Methodology: This study included 100 children with purulent discharge and bulbar conjunctival injection. Children either receivedmoxifloxacin 0.5% 4 times a day for 5 days or received tobramycin 0.3% eye drops (every 2 h for 2 days and then 4 times for5 days). Clinical signs were evaluated on days (D) 0, 3, and 7 and cultures on D0 and D7. The primary variable was the clinicalcure (absence of bulbar injection and discharge) on D3 in the worst eye for patients with positive culture on D0.Results: 100 culture-positive cases were included on D0. Moxifloxacin was superior to tobramycin in clinical cure rate on D3 (47.1%vs. 28.7%) P = 0.013) and was non-inferior to tobramycin on D7 (89.8% vs. 78.2%, respectively). Moxifloxacin treatment eradicatedcausative pathogens, including resistant species with a similar resolution rate to tobramycin (89.8% vs. 87.2%).Conclusion: Moxifloxacin 0.5% eye drops provided a more rapid and effective clinical cure than tobramycin 0.3% eye dropsin the treatment of purulent bacterial conjunctivitis in children, with 4 times dosing.
ABSTRACT
Aims and Objectives: The aim is to study the different corneal complications after manual small-incision cataract surgery(MSICS) and their implication on the final visual outcome in the patients.Design: It is a prospective, hospital-based observational study.Materials and Methods: The present study was done among 100 patients who underwent MSICS with implantation of posteriorchamber intraocular lens implantation. Study was conducted over a period of 3 months between March 2018 and May 2018 inGovernment Medical College, Jammu. All patients with clinically significant visual cataract admitted in Ophthalmology Departmentof Government Medical College, Jammu, during the study period were included. The post-operative corneal complications andbest corrected visual acuity (BCVA) of the enrolled patients were reviewed on the 1st, 7th, 15th, 30th, and 45th post-operative day.Results: 100 eyes of 100 patients consisting of 69 males and 31 females who underwent MSICS with intraocular lens implantationin the Department of Ophthalmology were studied. Majority of the patients belonged to the 60–69 years age group whichconstitutes 35 of the total patients. Out of 100 patients, 26 had corneal complications. 24 patients had striate keratopathy – outof whom 16 patients had mild grade striate keratopathy (<10 Descemet’s membrane folds [DMF]) and 8 patients had severegrade striate keratopathy (>10 DMF). 1 patient had microcystic corneal edema, and 1 patient had Descemet’s membranedetachment. After 6 weeks of post-cataract surgery, it was found that 89 patients achieved a BCVA of 6/9 or better.Conclusions: Corneal complications such as striate keratopathy are transient and resolve usually by the end of 2 weeks.Therefore, it was concluded that detailed pre-operative planning and careful surgery can prevent most of these complications.
ABSTRACT
Purpose: The purpose was to study dry eye following manual small-incision cataract surgery (SICS) by analyzing the changesin tear film and diagnostic tear film tests following cataract surgery.Study Design: This is a prospective study.Material and Methods: The present study is a hospital-based study which was carried out over a period of 1 year starting fromApril 2018 to March 2019. In this study, 50 patients of age group 31–80 years, who were diagnosed with senile cataract wereobserved. All underwent uncomplicated manual SICS and followed up for the period of 3 months. All selected patients werestudied for any abnormalities in tear film before and after manual SICS. The various tear film tests done were tear meniscusheight (TMH), tear film breakup time (TBUT), Schirmer’s test 1 (ST1), and rose bengal staining (RB). The tests were done onall the patients 1 day before and 1 day, 1 month, and 3 months post-cataract surgery.Results: In the present study, majority (50%) of the study participants were aged between 61 and 70 (years) and 18%were aged between 71 and 80 (years). In the present study, 70% of the participants were males and 30% were females. Alldry eye test values were significantly worse post-cataract surgery in the 3-month follow-up period; TMH analysis showedthat 22 (44%), 38 (76%), and 31 (62%) had low TMH at post-operative 1 week, 1 month, and 3 months, respectively,which was statistically significant. The TBUT analysis showed that at post-operative 1 week, 1 month, and 3 months,18 (36%), 23 (46%), and 18 (36%) had low TBUT values. 21 (42%), 26 (52%), and 9 (18%) had low ST1 values at postoperative 1 week, 1 month, and 3 months, respectively. RB stain analysis showed at 1 week, 1 month, and 3 months,post-operatively 21 (42%), 26 (52%), and 9 (18%), respectively, patients had abnormal value. Statistically significantdifference in TMH, ST1, TBUT, and RB staining between pre-operative, post-operative 1 week, 1 month, and 3 monthshas been seen.Conclusion: Manual SICS is capable of inducing dry eye, and patients should be educated about the dry eyes after cataractsurgery and be assessed for dry eyes pre-operatively