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A 3 month old infant exclusively breast fed presented with vomiting and poor weight gain with purpuric and echymotic patches all over the body. The child also had hyperpigmentation over knuckles and icterus. Laboratory investigations revealed severe dimorphic anemia with thrombocytopenia, elevated bilirubin and LDH levels and severe vitamin B12 deficiency. Following vitamin B12 supplementation there was improvement in well-being including feed tolerance, icterus resolved and in follow up lab studies there was improvement in hemoglobin and platelet counts along with reduced bilirubin levels. Through this case report we want to emphasize the possibility of vitamin B12 deficiency presenting as hemolytic anemia and psuedothrombotic microangiopathy.
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Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem inflammation and the presence of circulating autoantibodies directed against self-antigens. The reported prevalence of SLE in children and adolescents (1-6/100,000) is lower than that in adults (20-70/100,000). The study among pediatric population' were few and hence this study from south India was undertaken. Objective of this study was to study the clinical and immunological profile of children with systemic lupus erythematosus (SLE). To study the Distribution of Renal Lesions according to ISN/RPS Classification of Lupus Nephritis'Methods: Retrospective hospital based observational study in tertiary level centre in Bengaluru (BMCRI). Medical records of children with SLE admitted in Pediatric department from the period of 2010-2019 through the hospital information system were analyzed. Clinico pathological features and immunological profile were compared with other studies.Results: Among 25 patients studied male to female ratio was1:2.5. The mean patient's age at the time of presentation was13.2 year, the youngest child being 7 year. The mean duration of disease before diagnosis was 1year, most common systems involved were haematological (92%), followed by kidney (88%), GIT (72%), mucocutaneous (68%) cases. 19 (91%) cases were ANA positive and two ANA negatives. Anti-ds DNA was positive in 18(85%) patients, 5 were anti smith antibody positive. Diffuse proliferative glomerulonephritis (ISN/RPS class IV) was the most commonly seen histological pattern, seen in 9(56%) patients, 4(25%) patient had focal and segmental proliferative glomerulonephritis (ISN/RPS class III) and 2(12%) had membranous glomerulonephritis (grade ISN/RPS class V).Conclusions: SLE can present with diverse, unpredictable clinical manifestations, the primary diagnosis can often be missed if the index of suspicion is not high, since childhood SLE does not present with classical manifestations.
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Background: Determination of attitude and awareness towards epilepsy in general population. Despite successfully achievement of management of epilepsy in hospitals, the efforts to assess the awareness and mass education is very limited.Methods: Total 880 participants were required to answer a series of questionnaires related to demographic data, awareness, attitude towards epilepsy with details of their first aid management and their source of information for the same.Results: Concerning attitude, 14.65% would object having their children associated with epilepsy. 72.16% would object to marry or their children marrying an epileptic. 8.86% thought epilepsy as a form of insanity. Concerning knowledge, the 33% will seek others help as a first aid measure and 50% don't have any source of information regarding first aid management.Conclusions: The results indicate considerable amount of social stigma still exist and alarming fact was even the educated people still think it as a social stigma and are biased. Awareness needs to be enhanced through various knowledge campaigns. Stress on proper first aid measure to a seizing person needs to be addressed to remove fear and anxiety among the public.
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Background: Identifying common etiological organisms among cases of suspected sepsis and their sensitivity pattern for common antibiotics will help in initiating appropriate therapy. Finding association of positive culture with other markers of infection like total leucocyte count, haemoglobin, C-reactive protein.Methods: Descriptive and an observational study conducted in Kempegowda Institute of Medical Sciences, hospital paediatric intensive care unit, Bangalore, Karnataka, India. Data was collected prospectively. Duration of study was for 1 year from February 2018 to February 2019.Results: During the study, 52 cases admitted to paediatric intensive care unit were suspected to have sepsis and 91 samples were sent for culture. Out of these, 46 were blood, 34 were of urine and 11 others (pleural, CSF, ET). Among these samples tested 26% (18) of blood, 23.5% (8) of urine and 45.45% (5) of other samples showed organisms.Conclusions: In this study, author were able to know the common etiological agent involved in sepsis. Author were able to identify the antibiotic sensitivity patterns among various organism which provide valid data for initiation of appropriate treatment.
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Hypoplastic internal carotid artery has been reported in about 100 patients, most being incidentally diagnosed. Association with other anomalies rarely described. Authors report 6-year-old male presenting failure to gain weight and precordial bulge from past 6 months, past history was significant-diagnosed to have right dysplastic kidney at 8 months age. Detailed investigations revealed left hypoplastic internal carotid artery, vertebral segment anamoly, right dysplastic kidney due to right renal artery stenosis. Child was treated medically and was clinically better at latest follow up. All cases with dysplastic kidney need to be searched for vertebral and carotid anomalies, left ventricular dysfunction.
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A simple and straightforward method for the determination of dolasetron mesylate (DM) in aqueous solution was developed based on the fluorescence quenching of 3-Mercaptopropionic acid (MPA) capped CdS quantum dots (QDs). The structure, morphology, and optical properties of synthesized QDs were characterized by using UV-Vis absorption spectroscopy, fluorescence spectroscopy, transmission electron microscopy (TEM) and dynamic light scattering (DLS) measurements. Under the optimum conditions, the MPA-CdS QDs fluorescence probe offered good sensitivity and selectivity for detecting DM. The probe provided a highly specific selectivity and a linear detection of DM in the range of 2–40 μg/mL with detection limit (LOD) 1.512 μg/mL. The common excipients did not interfere in the proposed method. The fluorescence quenching mechanism of CdS QDs is also discussed. The developed sensor was applied to the quantification of DM in urine and human serum sample with satisfactory results.