ABSTRACT
Introduction: Recent studies of quality of life as what philosophers such as Plato, for centuries, has referred to the [good life] is defined
Objective: The goal of the present study was to investigate the prediction of the quality of life based on personality traits and the type of intelligence in women
Method: The research method was correlation. The population included all the married women in Markezi and Tehran provinces in 1914. 504 participants were chosen on the basis of cluster sampling. The tools of research were NEO questionnaire, cognitive, spiritual, emotional, moral, cultural intelligence questionnaires
Results: The results obtained from the analysis of the data showed that there was a significant positive relation between the quality of life and Extraversion, Agreeableness, Conscientiousness, Openness. Also there was a significant negative relation between the quality of life and Neuroticism. Also there was a significant positive relation between the quality of life and cognitive, spiritual, emotional, moral, cultural intelligences
Conclusion: According to the results of this study, knowledge of personality traits and the types of intelligence plays an important role in improving the quality of life
ABSTRACT
Toll-like receptors [TLRs] have been discovered as the most important receptors in innate immunity. One of the most important TLRs is TLR4, the key receptor for the LPS component of gram-negative bacteria. Two polymorphisms, D299G [rs4986790] and T399I [rs4986791], in TLR4 gene are associated with a decreased response to LPS. This study was done to estimate the expression of different polymorphisms of TLR4 gene in colorectal cancer cell line by flowcytometery. In this laboratory study, the HCT116 cells were transfected with plasmids containing different variants of TLR4 gene including; Flag-tagged-TLR4 wild type, flag-tagged D299G and T399I Using TurboFect transfection reagent. Transfection efficiency was evaluated by GFP plasmid. Expression of different variants of TLR4 was assessed in transfected cells by flowcytometery. Data were analyzed using SPSS-11.5 and chi-square test. TLR4 was detected on HT29 and CaCo[2] cell lines at low levels. HCT116 cells did not express detectable amounts of TLR4 by flowcytometery prior to transfection. Gene transfer efficiency for GFP plasmid was about 80% in HCT116 cells by flowcytometery and microscopic analysis. TLR4 expression and LPS responsiveness significantly was higher in HCT116 cells which were transfected with wild type TLR4 gene compared to non-transfected and mutant transfected cells [P<0.05]. Lower expression of TLR4 on cells with mutant TLR4 showed that these polymorphisms affect on expression patterns of TLR4 on colon cancer cells
ABSTRACT
Antibiotics usage in domestic animals, as antibiotic growth promoters [AGPs] was considered from middle of 1950 onwards. Antibiotic feed additives as growth promoters have long been supplemented to animal food in very low amounts [5 to 20 ppm] to stabilize the intestinal microbial flora, improve the general performances, and prevent some specific intestinal pathogens. The widespread use of antibiotics as AGPs is playing a significant role in the emergence of resistant bacteria. The resistant bacteria in animals due to antibiotic exposure can be transmitted to human through the consumption of their products, from close or direct contact with animals, or through the environment and consequently, the increased concern about the potential for antibiotic resistant bacteria was led the European Union and the United States regulations banning the use of AGPs in animal food since 2006. Various studies always look for a suitable replacement antibiotics to substitute to preserve the valuable role of these compounds. Extensive efforts on these alternatives have been started in last decades and some of these alternatives such as probiotics, prebiotics, synbiotics, ionophores, acidifier, organic acids, medicinal herbs and phytogenic can be pointed out. Hence, the aim of this review is to evaluate the antibiotic replacement strategy particularly medicinal herbs and their mechanisms as new growth and health promoters