ABSTRACT
The effect of IL 28 B polymorphism on sustained virology response [SVR] in patients with Hepatitis C genotype 1 varies among races. Multiple studies have shown that the SVR is two or three times higher in patients with CC genotype compared to those with TT genotype. This study aims to assess the relationship between IL 28 B polymorphism and SVR in Iranian patients. Materials and In a cross-sectional study, 48 patients with Hepatitis C genotype 1 who underwent PCR testing six months following treatment were divided into two groups, SVR positive and negative in order to compare IL 28 B polymorphism. The SVR rate was higher in patients who presented with high baseline ALT levels, independent of IL 28 B genotype [p=0.023]. Logistic regression analysis showed a higher SVR rate in patients with CC genotype compared to TT genotype [p=0.007, OR=29.333, CI=2.558-336.387], however no significant difference was noted between TC and TT genotypes [p=0.177, OR=2.887, CI=0.618-13.496]. Additionally, there was a significant difference between CC and non-CC groups [TC, TT] in SVR rate [p=0.017, OR=13.750, CI=1.602- 118.061]. A high SVR rate was seen in the C group [CC, TC] when compared with the TT genotype [p=0.036, OR=4.923, CI=1.111-21.816]. The sensitivity, specificity, PPV and NPV of the IL 28 B genotype in predicting SVR was 88.8%, 38%, 64.8% and 72.8%, respectively. In addition; although the CC genotype was positive, the sensitivity and NPV were increased to 91.6% and 95.2% respectively. This study confirms the relationship between IL 28 B genotype and SVR rate in the patients with Hepatitis C genotype 1. It seems; IL 28 B genotype could be the reasonable Lab. test for treatment plan of the problematic cases of the patients with Chronic Hepatitis C
ABSTRACT
Management of military medicine service during a war faces two major kinds of weapons, conventional and unconventional.Now a days,production and application of unconventional agents and weapons of mass destruction [chemical,biological,nuclear and remote control weapons] which are called new arsenal, threaten more and more the health and life of living things and human beings every day. Super powers use these kinds of weapons for their sovereignty on other countries.The main goal of military medicine management is to maintain the health of military staff during war and peace with increasing the awareness of personnels by functional methods.The objective of this article is to emphasise roles of management of military medicine in defence during new wars. This is an original article in which the records of imposed war and the pattern of military health management in modern war counterattacks and the evidence from countries involved in these kinds of wars and crisis are mentioned and Persian and English literature were used as examples. Results show that the responsibility of military health management in modern war counterattacks is not just limited to the times of war and crisis; these issues should also be considered in the peace time as well as war and crisis in order to achieve its objectives. Preparation, providing required conditions, and acquiring information about weapons, their application and the methods to tackle them, should all be done in this phase and necessary training should be provided for military personnels and people who are in danger. Debate on using modern weapons is now of great importance since the types of weapon and their destructive effects -even if used in a limited level- have been changed. Ignoring this issue can easily affect the moral and military capabilities of ordinary people as well as military personnel and has a special importance. Although the application of these weapons may not be as widespread as before, current destructive effects of these weapons is now much greater than before. Special attention should be paid to this issue