Antioxidant activity of aerial parts of tribulus alatus in rats

The antioxidant activity of alcoholic extract of Tribulus alatus was investigated by determination of blood glutathione, serum ascorbic acid and serum superoxide dismutase in rats. All groups treated with aerial parts without fruit, fruits and total herb showed a significant increase in all measured parameters [P<0.05]. Upon fractionation of the alcoholic extracts using solvents with different polarities, all fractions revealed a significant increase in serum superoxide dismutase [P<0.05]. On the other hand chloroformic fraction of aerial parts without fruit extract and ethylacetate fraction of fruits extract exhibited a significant increase in blood glutathione level. All fractions of fruits extract, chloroformic and ethylacetate fractions of aerial parts without fruit extract significantly increase the serum ascorbic acid concentration [P<0.05]

Schistosomiasis in chronic cervicitis [prevalence and pathological effect]

Histopathological examination of the cervix of 200 patients complaining of chronic cervicitis with positive urine or stool analysis, for schistosomiasis showed 8 cases of schistosomal infection [4%] varying degree of cellular abnormalities were associated with schistosomal infection in the form of 2 cases with cellular atypia, one case with well differentiated squamous cell carcinoma and one case with well differentiated adenocarcinoma. The high percentage of cases with cellular abnormalities [50%] among patient with schistosomal cervical infection together with its incidence in relatively younger patients are strong evidences that schistosomiasis may have a carcinogenic effect on the cervix

Synthesis of furo [3,2-g] coumarin derivatives, likely to posses antimicrobial activity

The reaction of fuming nitric acid with bergapten [I] and xanthotoxin [II] afforded the corresponding nitro derivatives [IV and V, respectively]. With imperatorin [III] the reacted with imperatorin [III] to give the phenolic compound a nitrogen-free compound [VII] resulted. Molecular bromine reacted with bergapten [VIIIa-c] in a mixture, and with xanthotoxin [II] to produce the 5-bromo derivative [IX]. Anomalously, molecular bromine reacted with imperatorin [III] to give the phenolic compound 5-bromo-9-hydroxy-furo [3,2-g] coumarin [X]. Structures of all of the final products [VIX] were confirmed by IR, H NMR and mass spectral data