ABSTRACT
Background: Polycystic ovary syndrome [PCOS] as a common cause of infertility is the endocrine disorder among reproductive-aged women. Nevertheless, the management and treatment of this major problem is not deterministic, and surrounded by many controversies
Objective: In this study the effects of betanin, as red pigment present in red beetroot, in the PCOS induced rats are evaluated
Methods: Sodium valerate was injected intraperitoneally into wistar female rats to induce PCOS for 25 days. The rats were randomly divided into five groups: a normal control group without sodium valerate, Sham [sodium valerate-induced PCOS] group received 0.5 ml distilled water , metformin group and two groups that received betanin at doses of 8 and 16 mg/kg/ day for 30 days after they were administered sodium valerate. The Glucose, lipid profile, gonadotropine hormones were determined using calorimetric assays in PCOS induced rats. Histological examinations were carried out on hematoxylin-eosin stained sections using light microscopy
Results: When compared with sham, betanin caused low ovarian cysts with a high incidence of ovarian primary, antral, graafian follicles and corpus luteum. The plasma glucose, cholesterol, LDL and LH levels were found to be diminished significantly in rats with PCOS whereas plasma HDL and FSH levels were significantly increased
Conclusion: The betanin affected the cysts and follicles of the PCOS induced rats
ABSTRACT
Intracellular adhesion molecule-1 is one of the factors associating obesity and inflammatory lesions like atherosclerosis. This study examined the effects of resistance [R] and endurance [E] training on serum levels of slCAM-1 and lipid profiles in sedentary obese women. Participants included 24 [8 control, 8 RT and 8 ET] obese [BMI>30] women, studied before and after 10 weeks of resistance training [40-60% of 1RM] and swimming endurance training [at 50-60% of HRmax], 3 days/week. Serum levels of slCAM-1, lipid profiles and anthropometric indices were measured at baseline and again 48 hours after training. Statistical analysis was done by paired t-test. ANOVA and Pearson correlation, and P value<0.05 was considered significant. Levels of slCAM-1 [P=0.042], cholesterol [P=0.006] and HDL-C [P=0.006] changed significantly following 10 weeks of endurance and resistance training compared to those of the control group. There was significant decrease in serum levels of slCAM-1 in the both RT [P=0.012, 21.7%] and ET groups [P=0.017, 18.4%]. Although significant changes did not exist in lipid profiles after resistance training [p>0.05], TG [P=0.001], cholesterol [P=0.043] and HDL-C [P=0.002] changed significantly in the endurance training group. Hence there were significant correlations between the primary level of slCAM-1 and primary values of BF% [P=0.031], pelvic [P=0.005] and waist [P=0.006] circumferences following endurance training, whereas changes in the levels of slCAM-1 or lipid profiles and anthropometric markers did not correlate significantly in the resistance training group [p>0.05]. Although decrease in slCAM-1 level may be associated with the beneficial effects of training on body composition or/and lipid profile, further studies are needed to elucidate the mechanisms responsible for the effects of resistance training on ICAM-1 level
ABSTRACT
The coexistence of Waldenstrom's macrglobulinemia and cryptogenic cirrhosis has been rarely reported.We describe a 72-year-old man with compensated cryptogenic cirrhosis whose major clinical presentation was hyperviscosity syndrome. Serum protein electrophoresis revealed the presence of an IgM-kappa spike. Lambda light chain was found in urine. Bone marrow biopsy was performed, which showed at least 22%infiltration with atypical plasma cells. No bone lesion was found. ByWaldenstrom'smacroglobulinemia diagnosis, patient treated with melphalan, thalidomide and dexamethasone. After three weeks of treatment, his symptoms disappeared and serum immunoglobuline M decreased below 1000 mg/dl