ABSTRACT
Background and Objective: Polycystic ovary syndrome [PCOS] is the most endocrine disorder in women. This study was done to determine the effect of N-acetylcysteine with letrozole to induction of ovulation in infertile women with polycystic ovarian syndrome
Methods: This clinical trail study was carried out on forty PCOS women with normal TSH, prolactin, hysterosalpingographies and normal spermograms. The patients in control group were received letrozole 5 mg/d for 5 days starting at day 3 of the cycle. The patients in interventional group were received letrozole 5 mg/d with NAC 1.2 g/d [group II] for 5 days starting at day 3 of the cycle. On 14[th] day of cycle, transvaginal ultrasonography was performed to evaluate endometrial thickness and follicles properties. If mature follicle detected, hCG was injected and timed coitus at 12, 36 and 60 hours later advised. beta-hCG level was checked on day 16 after hCG injection
Results: The mean of endometrial thickness and follicles ovulation in hCG injection day was similar in the two groups. The pregnancy rate was 15% and 20% in control and interventional groups, respectively. This difference was not significant. The mean of follicles number was 1.13% and 1.47% in control and interventional groups, respectively. This difference was not significant
Conclusion: NAC as an adjuvant to letrozole was not effective for ovulation induction in patients with PCOS
ABSTRACT
Background and Aim: Anemia is the most prevalent nutritional deficiency in the world, affecting almost 30% of people worldwide, especially the pregnant women
On the other hand preterm birth is responsible for 2/3 of the infant mortality rate; therefore we performed this study to find the relationship between hemoglobin level in the first trimester of pregnancy and preterm delivery
Material and Methods: This descriptive-analytical study was performed in the years 1392 - 1393 in Qazvin Province. 3000 pregnant women [age range:!8 - 40 years], with gestational age of less than 12 weeks were selected from 5 medical health centers. 284 participants were excluded because of IUFD, anomalies, abortion, lack of cooperation or referral to other centers for follow up or performance of lab. tests. The first trimester Hb was recorded in a questionaire for every subject and cases were observed for spontaneous preterm delivery [less than 37 weeks]
Using SPSS 16 software, data were analyzed by chi -square test, T- test andlogestic regression
Results: In this study the prevalence rates of anemia and preterm birth were 22.2% and 19.9% [542 cases] respectively. Mean gestational age was 38.28 +/- 3.56 and the rate of preterm birth in the subjects with normal Hb level was 19.3%, and 21.9% in the patients with anemia, which revealed a significant relationship between maternal anemia and preterm birth [p <0.008]
Also the relative risk for preterm delivery in anemic women was 1.117, CI: 95% [1.09 - 1.46] [P-0.046]
Conclusion: This study demonstrated the relationship between maternal anemia in the first trimester and preterm birth
Therefore, preconception evaluation and anemia treatment in the women of chMbearing age is recommended
ABSTRACT
Identification of factors preventing preeclampsia in high risk pregnant women is of prime importance. The omega-3 supplementation may reduce the risk of preeclampsia. The aim of the present study was to assess the effects of omega-3 supplementation on high risk pregnancy for preeclampsia in the city of Qazvin. This was a single-blind randomized clinical trial conducted on 100 high risk pregnant women for preeclampsia over a period between 14 to 18 weeks of gestation in the city of Qazvin, Iran. Fifty patients were assigned to omega-3 group and another 50 to placebo group. Women were given a daily supplementation of 1000mg omega-3 or placebo until delivery. Later, preeclampsia and pregnancy outcome were assessed in both groups. Data were analyzed statistically using t-test, chi square test, Mannwhitney, and Fisher exact tests. There were significant differences between the omega-3 and placebo groups regarding the rate [p=0.015] and intensity [p=0.01] of preeclampsia. Statistically, a significant correlation between the omega-3 group and outcome of pregnancy including the birth weight [p=0.000] and apgar score [p=0.002] was found. Our results suggest that supplementation with omega-3 during pregnancy reduces the risk of preeclampsia in high risk pregnant women. Thus it seems necessary to promote educational programs on nutrition for pregnant women