ABSTRACT
During recent years, many epidemiological studies on risk factors of cardiovascular disease [CVD] have been performed among which are fibrinogen, activity of factor VII, lipoprotein [a], and homocysteine as new CVD risk factors. Through completed studies, it is found that in urban population of Isfahan more than one risk factor [hypertension, smoking, hypercholesterolemia, diabetes and obesity are seen in 32% of men and a descriptive cross-sectional study was performed in 1998-99 and 409 subjects [175 men, 234 women] were randomly sample. Then each subject underwent a blood test, electrocardiography, medical examination and daily physical activity assessment. Nutrient intakes were obtained through assessment of food consumption as 3-day recall. Personal information and anthropometric measurements were also recorded. Fast blood sugar and serum lipids were measured by auto analyzer Elan 2000; lipoprotein [a] by ELISA; hemocystein by HPLC; fibrinogen by turbidimetry and factor VII by calculating coagulation time compared to standard time. Statistical analyses were done by t-tests. The results showed that mean fibrinogen, factor VII, lipoprotein [a], and hemocystein were 244.9+/-7 mg/dl, 118.3+/-58 per cent. 13.3+/-13 mg/dl and 11.5+/-3 micro mol/lit respectively in studied population. By comparing these new CVD risk factors over the world, it was determined that their- levels were in the normal range in urban population of Isfahan. The level of fibrinogen and hemocystein are higher and lower in women than those in men, respectively that is compatible with many other studies