ABSTRACT
Background: The potential effect of exercise training with supplementation in improving fat metabolism and complications of lipid disorders is an interesting subject
Objective: The aim of this study was to investigate the effect of high intensity interval training and flax seed oil supplementation on liver and intestine ABCA1, SR-BI, ABCG1, LXR gene expression, as well as the concentration of HDL, LCAT and plasma lipids in male rats
Methods: Forty adult Wistar rats were randomly divided into eight groups [n=5] including control-saline, training-saline, control-flaxseed oil [With 3 doses], and training-flaxseed oil. The training groups were given high-intensity interval training [10 weeks, five sessions in week] on a rodent treadmill at 90-95% of VO2max and supplement groups also received flaxseed oil with three different doses [10, 20 and 30 mg/kg per cage]. Then rats were sacrificed and samples were collected
Results: The results showed that the training created a significant increase [P<0.01] in the expression of liver ABCA1 and ABCG1genes, intestine ABCA1, LXR and SRBI genes, as well as the plasma HDL and LCAT concentration. Supplements caused a significant decrease [P<0.001] in expression of liver ABCA1 genes. There was a significant and positive correlation between liver ABCG1 gene expression with plasma HDL and LCAT, as well as between intestine LXR gene expression with plasma HDL
Conclusion: Long-term consumption of even unsaturated oils may have adverse effects on the cardiovascular system, but high intensity interval training can bring health benefits by increasing the expression of genes involved in reverse cholesterol transport
ABSTRACT
Background and Objective: Extensive exercise may be disrupting oxidant and antioxidant balance and cause the phenomenon of oxidative stress in human and decrease athletics performance. This study was done to determine the effect of coenzyme Q10 supplementation for two weeks on markers of lipid peroxidation in soccer player
Methods: In this queze - experimental study, 36 soccer players [mean age, 20.08 +/- 1.12 years, weight 63.28 +/- 1.65 kg and maximal oxygen uptake 53.12 +/- 0.98 ml per kg/bw] divided into three groups for 14 days and the desired experiment was done during this period of time. Soccer players in control group did not receive the supplements and exercise. Subjects in placebo group were received 5 mg/kg/bw aspartame capsules. Subjects in supplement group were received 5 mg/kg/bw of Ubiquinone-10. Soccer players also performed two 90-minute soccer matches with less than 48 hours. Blood samples 24 hours before and after the period were collected. Malondialdehyde [MDA], lactate dehydrogenase [LDH], creatine kinase [CK] and aspartate aminotransferase [AST] levels were measured
Results: Serum level of MDA and AST after two consecutive football matches was significantly increased in the placebo group in compared to supplementation and placebo groups [P<0.05]. The serum levels of AST and MDA in supplementation group did not significantly increased when compared to control and placebo groups
Conclusion: Short-term supplementation of coenzyme Q10 before and during of the two consecutive soccer matches can prevent the elevation of lipid Peroxidation indeces