ABSTRACT
SCL-90-R inventory is used for screening and assessing effect of some treatment. Its sensitivity depended on environmental factors; there are many shortcomings of its normalization in our community. To normalize SCL-90-R inventory in Guilan high-school students in the years of 2003-2004. In a cross-sectional study, 4015 subjects were selected of 153948 students using multistage cluster sampling. New version of Persian SCL-90 R, that its content validity and reliability were examined and proved [r=0.86] was used. We determined validity and reliability of new version and prepared normal tables. Data was processed with SPSS 11.5 and analyzed by appropriate statistical tests [alpha=0.05]. There were 2005 females and 2010 males that 1242 subjects were in 3rd grade and 1341 subjects were in 17 years age group. The most reliability coefficient found for depression; with test retest [r=0.93], splitting [r=0.85]; and Crunbach alpha [r=0.85]. There was a correlation between all 9 factors and with three global indices [r>0.50] and between 9 dimension of SCL-90-R and MMPI scales, that most correlation were between depression and anxiety [SCL-90-R] with neurasthenia in MMPI [r=0.59]; and compulsive-obsessive, psychosis with schizophrenia [r=0.58] we found a statistical correlation between two tests [alpha=0.05]. There was most mean and standard deviation [1.58 and 0.76 respectively] in females and in males [1.41 and 0.71 respectively] for paranoid scales. We found GSI mean and standard deviation 1.16 and 0.59 in females and 0.92 and 0.49 in males respectively with statistically significant difference [alpha= 0.05]. Our new Persian version of SCL-90-R inventory has acceptable validity and reliability: and can be used as measurement a general psychological symptoms in Guilan students
Subject(s)
Humans , Male , Female , Adolescent , Personality Assessment , MMPI , Students/psychologyABSTRACT
Background: oxidative stress is one of important risk factors of deiseases specially in military recruits who are under sever practices Vitamin C is one of the major antioxidant factors which also help to increase iron absorption. Vitamin C and probably iron deficiency due to that, can decrease soldier forces and cause various diseases particularly pulmonary diseases. The purpose of this study is to determine serum level of vitamin C and iron and TIBC in military recruits to prevent following problems due to deficiency of Vitamin C
Materials and Methods: This study was done as a cross-sectional study in September 2007 in Tehran and 51 soldiers were chosen randomly who were between 17 and 24 year sold. 5 cc blood was collected for determining serum vitamin C, iron and TIBC. Prevalence of vitamin C and iron deficiency and relationship between vitamin C and iron serum levels and between vitamin C and iron serum levels and between vitamin C and TIBC serum levels were calculated
Results: Mean value of serum level of vitamin C 0.57 +/- 0.23 SD was less than normal range. [0.6-2 mg/dl], and prevalence of vitamin C deficiency among the soldiers of this study was 56.8%. However, mean value of serum iron 102.57 +/- 53.78 mg/dl SD was in normal range [60-180 mg0dl] and also TIBC amounts 364.51 +/- 59.00 mg/dl SD was in normal range [230-410 mg/dl]. Relationship between vitamin C and TIBC serum levels was reversely significant [P<0.001]
Conclusions: It is advisable to get more attention to provide more vitamin C resources for young soldiers for preventing to iron deficiency status or other potent dangers
ABSTRACT
Introduction: New anti psychotic drugs [atypical] have fewer extra pyramidal adverse effects and more therapeutic effects in comparison with the old ones. There is no agreement on the effects of new antipsychotics on the BMI and rising blood glucose
Objective: This study was done to investigate above adverse effects [raising blood glucose and BMI] in the psychotic patients who were treated with Olanzapine in Shafa hospital and private clinic during 2005-2006
Materials and Methods: In this descriptive- analytic [study a population in two periods of time] 150 individuals who referred to previous mentioned centers were chosen. Inclusion Criteria were: diagnosis of psychosis according to DSMIV, using Olanzapine as treatment and having FBS less than 110 mg/lit. Exclusion criteria included: those who had inadequate response or had no tolerance to Olanzapine, users of other psychothropic and substance and those who had received long term Antipsychotics during the last month. Their BMI and fasting blood glucose were measured before and after the study. More over, some variables such as the history of Diabetes Mellitus in the family, type of psychosis, gender and age were asked through an specific questionnaire which had been designed for this purpose. Then we collected the data in two periods. These data were analyzed through SPSS 11/5 while using the appropriate statistical tool and alpha=0.05 was accepted
Results: From total 150 individuals 79[52/7%] were female and 71[47/3%] were male. 16 of them had a FBS more than 110 mg/d lit. 11[7/33%] individuals showed Diabetes and 5[3/33%] individuals showed some disturbance in FBS. There were significant difference between the mean changes of blood glucose [paired t p<0.0001] and also average body mass index changes [paired t p<0/0001] before and after treatment was statistically significant. There were no significant correlation between changes of body mass index and fasting blood glucose in base and end point [p=0/218,0/249]. Among studied variables, the most significant relationship statistically was with changes of FBS and Olanzapine 10 mg a day [p<0.006] and ages over 45 p<0.006. Changes of fasting blood glucose had a marginal relationship with schizophrenia [p=0.55], and the other variables [such as gender, family history of Diabetes] had no statistically significant relationship with the changes of glucose level. There was also no relationship between the gender and the incidence of diabetes [p=0.68]. There are significant difference between changes of FBS and using more than 10 mg daily Olanzapine [p<0/006] and also between changes of FBS and ages over 45[p<0.006] and schizophrenic patients p=0.055
Conclusion: This study demonstrated that mean changes of fasting blood glucose and BMI after using Olanzapine in psychotic patients is statistically significant. Prescription of Olanzapine in schizophrenic patients who are over 45 and those who use more than 10mg a day of Olanzapine should be done more cautiously. Additional investigation by using clinical trial would offer more precise results