ABSTRACT
Considering the rising prevalence of HIV infection, hepatitis Band hepatitis C epidemics in our country and other developing countries, and given that these blood-borne pathogens could be acquired through occupational exposure as a major professional hazard among healthcare workers, such as physicians, nurses, dentists, laboratory workers, and cleaning service employees by needle stick injury or splashing of infected fluid to mucosal surfaces, doctors, nurses and other health-care providers are worried about HIV, HBV and HCV exposure and, after such accidents, they ask "is this disease transmitted to me?". So, all of healthcare workers should be educated for post-exposure prophylaxis of blood-borne pathogens. This review is based on the last recommendations and current protocols for prompt reporting, evaluation, counseling, treatment, and follow-up of occupational exposure to blood-borne pathogens