Therapeutic assessment ofAntrokinon on minor oral aphthous lesions

Antrokinon is an herbal compound with anti-inflammatory properties. This substance is usually used for treatment of skin lesions and burns. The aim of this study was to assess the clinical therapeutic effects of Antrokinon on oral aphthous lesions. In a double blind clinical trial study, the therapeutic effect of Antrokinon was evaluated against placebo in 80 individuals attending the school of Dentistry, Mashhad University of Medical Sciences. To receive dental treatment. The Antrokinon and placebo were exactly similar in color and they were in drop form [5cc]. Five drops of drug or placebo were instructed to be used locally, 4 times a day, in regular intervals. The collected data was analyzed using Mann-Whitney U test at 95% confidence level [P < 0.05]. The statistical analysis showed that, the drug had positive effects on clinical improvement of aphthous lesions in the oral cavity when compared with placebo. A significant decrease in clinical wound healing time was observed after using the drug in comparison with placebo [P = 0.001]. Likewise, Mann-Whitney U test revealed that the, burn-healing time was significantly shortened in comparison with placebo group as well [P = 0.003]. Useing Antrokinon can significantly decrease both, the wound-healing time and burn-healing period in oral aphthous lesions

[Effect of high dose of oral amoxicilin on local lymphadenopathies of the head and neck]

Most of solitary head and neck lymphadenopathic patients, due to similar symptoms and histories, are evaluated by special paraclinical tests and even unneccessary biopsies. The aim of this study was to investigate the effect of high does of oral amoxicilin on solitary head and neck lymphadenopathies during a limited period of time. This descriptive-interventional study was conducted in census form. The experimental populations were solitary head and neck lymphadenopathic patients suffering for a period of less than two months with the lymph node size of 1.5 cm or more. Patients with weight of more than 27 kg, were treated by 2 gr of amoxicilin every six hours for three days and received the drug daily as follow up. For individuals weighted less than 27 kg, the drug was prescribed as 100 mg / kg daily divided in four equal doses. At the end of the third day to the end of the seventh day from the treatment onset, amoxicilin offering was continued by a lower dose of one gram every six hours. Data obtained on the lymph node size were analyzed using Mann-Whitney test [p < 0/05]. Seventeen patients developed complete improvement, but eight did not respond to this treatment regimen. The failure was found to be due to the existence of tumoral tissue, infection or treatment resistance, and lymphocytic infiltration without any particular etiology in two, two, and remaining four cases, respectively. According to the results of this study, it is concluded that prescribing high dose of amoxicillin, for a limited period of time, for all questionable solitary head and neck lymphadenopathic patients, considering the previous descriptive conditions, would be a useful diagnostic-treating approach

[Assessment of prevalence of median rhomboid glossitis in diabetic patients referring to Mashhad diabetes mellitus research center in 2005]

Diabetes mellitus is one of the most common disorders of endocrine glands, which causes various complications including the increase of susceptibility to many infections such as oral candidiasis. The purpose of the present study was to investigate the association between median rhomboid glossitis [MRG] and diabetes mellitus. In this descriptive study 200 patients were selected randomly from Khorasan diabetes mellitus research center. The data were collected through a questionnaire and oral examination. The data were analyzed using Mann Whitney test, Exact-Fisher test. In the present study, 19% of the diabetic patients male and 81% were female. The examination indicated that 7% of the diabetic patients had MRG. None of the males had MRG and 8.6% of the females had MRG. The highest frequency of MRG-infection was observed in patients over 40 years old, particularly in the age group of 70-79 years old prevalence of MRG was 14.3%. In this study the prevalence of MRG in diabetic patients was 7%

[Oral manifestations of patients with congenital heart disease]

Congenital heart disease [CHD] can have oral manifestations that even the patient may not be aware of. These manifestations could be linked to the disease itself or the treatment associated with it. Also, since a history of CHD may alter the treatment plan of some of the oral diseases or some oral diseases may affect the course of CHD, the current research was designed to better understand such interrelationships. In this cross-sectional descriptive study, 42 CHD patients that were admitted to the department of Internal Medicine of Imam Reza Hospital, Mashhad, Iran, were randomly investigated for a period of one year through a questionnaire and routine examinations and the final results are descriptively presented. In 17 cases [40.5%], cyanotic mucosa was reported and in 6 cases [14.4%] pale tissues were noted. In 2 cases cleft palate [4.7%] and cleft lips [4.7%] were recorded. Oral manifestations recorded for patients with CHD were Cyanosis, pale tissues and cleft and palatte and lip. Although clefting and palate lip can not be directly linked to CHD, their presence in conjunction with CHD should be considered

[Evaluation of some of the S.C.C. risk factors in patients referring to dental school and Omid hospital in Mashhad from September 2002 to September 2003]

Oral squamous cell carcinoma [S.C.C] is the most frequent malignancy in the mouth corresponding to 95% of all oral malignant lesions. The ultimate aim of treatment of cancerous patients is definitive cure and improvement of quality of life. The aim of this study was evaluating the effects of some risk factors in S.C.C patients. 54 patients suffering from oral S.C.C were studied in this descriptive study. 10 patients were selected from Mashhad dental school and 44 patients from Omid hospital in Mashhad [September 22, 2002 to September 22, 2003]. A questionnaire including patient and treatment related risk factors was filled for each patient. Risk factors consisted of sex, age, occupation, addiction to smoking, either cigarette, snuff or alcohol. Other items such as kind of treatment, staging of tumor and involved site were also included in the questionnaire. Statistical analysis was carried out by chi-square test. 52% of the patients were female and 48% were male. Totally, 93% of the patients were over 40 years old. 72% of the patients were addicted to cigarette and other tobacco compounds. The most common sites involved were tongue, buccal mucosa and inferior Lip. The main treatment of cancerous patients was radiotherapy. 36 patients received radiotherapy, 12 patients received radiotherapy and surgery, 1 patient received chemotherapy and the other 5 received chemotherapy and radiotherapy. In this study, 93% of the involvement was observed above 40 years of age. Tongue was the most common site involved [27.7%]. In our study, 67% of the women and 77% of the men had a history of smoking. The considerable point is high frequency of lower lip S.C.C. in male farmers who were under sun exposure. Sex did not affect SCC ivolvement in our study

[ comparative study on the clinical diagnosis and pathology report of patients undergone biopsy at department of oral medicine of Mashhad dental school from 2002 until 2004]

The purpose of this study was to evaluate the concordance between clinical diagnosis and pathology report of patients referring to department of oral medicine of Mashhad dental school. In this descriptive retrospective study, personal information and disease [or lesion] characteristics of 170 patients who had been referred to the department of oral medicine for biopsy during the past 2 years, were collected through questionnaires and were analyzed Chi-square and Fisher exat statistical tests. The diagrams were drawn with use of Microsoft office SPSS software. 81.2% of the clinical diagnosis were consistent with pathology reports. In 18.8%, the clinical diagnosis was not confirmed histopathologically. The greatest concordance was observed for lichen planus, inflammatory hyperplasia and leukoplakia whereas pemphigus, SCC and systemic lupus erythematosus revealed the lowest concordance. Although a great concordance was observed between clinical diagnosis and pathology report, the inconcordance was significant and establishing strategies for minimizing it, is necessitated