ABSTRACT
Polyethylene glycols [PEGs] are widely used in pharmaceutical preparations inspite of their known potentin vitro fusigenic properties. The subject of this note is to demonstrate that similar fusion can take place when these agents are administered to laboratory animals. Fusigenicity as observed by direct microscopic examination, and alsoby monitoring protective activity that cell fusion provides against ulcer formation by indomethacin. Rectal or oral administration of PEGs was found to result in histological alterations, suggesting fusion of mucosal cells. Also, high molecular weight PEGs were found to provide the stomach with protection against indomethacin induced ulceration, following oral administration to rats
Subject(s)
Animals, Laboratory , Ulcer/drug therapy , Cell Fusion , Indomethacin/adverse effects , Rats , Histological Techniques , Microscopy, ElectronABSTRACT
A field trial in Egypt of the plant molluscicide Anagallis arvensis is described. The application of 132 and 100 mg/Litre powdered whole plant material was made to drain water in October and November 1989. The treatment effect took 24 hours to become fully established. The reduction in the number of alive Biomphalaria alexandria, Bulinus truncates and Lymnaea natalensis was generally more than 90% at a concentration of 100 mg/Liter dry powdered plant material. Lymnaea natalensis snails showed the highest susceptibility to the action of both sooked and dry powder at the different concentrations used. The easy availability of the plant in the rural areas, the high molluscicidal activity of the dry powder of whole plant material and the simple technique of its application recommend the field application of Anagallis arvensis for snail control
Subject(s)
Plants, MedicinalABSTRACT
The crude triterpenoid saponins and tannins isolated from the ethanol extract of Sesbania aegyptiaca showed molluscicidal activity against B. alex and rina, LC power down 90 at 40 and 125 ppm, respectively. B- amyrin, oleanolic acid and dustanin were isolated and characterized
Subject(s)
Saponins , Tannins , Plants, Toxic , InsecticidesABSTRACT
The susceptibility of Lymnaea cailliaudi to the action of the crude saponins obtained by boiled water extraction of A. attenuata and F. gigantea was determined. The effect of some initiated field conditions on the activity of these crude saponins was investigated
Subject(s)
Plant Extracts , Fascioliasis , Pest Control, BiologicalABSTRACT
The susceptibility of the fascioliasis intermediate host lymnaea cailliaudi to the toxicity of the boiled water extracts of Agave filifera and Agave lophantha has been to amount, in LC[90] expression, to 11 and 19.4 mg/L respectively post exposure period of 24 hours. The steroidal saponin active consitutuents in yields of 5% and 3.6% in their water exbvocts showed much higher activity than they gave after their isolation from the water extracts. The activity of theses active saponins has been found to be stable under the effect of sunlight, high mud concentration and a wide range of temperatures and significantly increased by increasing the exposure period to 48 hours. The use of water for extraction provides an economic importance and possibly simple technique in field application
Subject(s)
Plant Extracts , Fascioliasis , Pest Control, BiologicalABSTRACT
The comparative susceptibility of adult Biomphalaria alexandrina, Bulinus truncatus and Lymnaea cailliaudi to the action of the crude saponins in the water extracts of A. decepiens and A. americana was determined. The activity of the active constituents showed stability under the effect of sun light, pH 4-10, temperature changes 10-30?C and high mud concentrations, against B. alexandrina, at concentrations necessary for 100% mortality. Storage of the aquous extracts affected a significant activity depression as a result of rapid biodegradation. The use of water for extraction adds to the economic importance of these plants for field application