ABSTRACT
Forty adult patients scheduled for minor urological surgical procedures were randomly allocated to two equal groups for anaesthesia. One group was administered propofol, a new class of intravenous anaesthetic agents chemically unrelated to the barbiturates, steroid or eugenol agents, the other group was given midazolam, a new short-acting benzo-diazepine. In both groups this was followed by fentanyl and nitrous oxide, but in the midazolam group flumazenil, a specific benzodiazepine antagonist, was administered at the end of surgery. Both techniques provided good-quality anaesthesia, and there was no difference in recovery times as judged by the patients' ability to open their eyes and give their date of birth. However, those who received propofol were able to sit up unaided significantly earlier and also to carry out the Postbox and Letter Deletion Tests significantly faster. After flumazenil reversal there was no significant difference in the sedation score for 30 min, but this was followed by a significant degree of resedation. The incidence of nausea, vomiting and headache were the same in both groups. This study showed propofol to be superior to midizolam followed by flumazenil reversal as the intravenous component of outpatient anaesthesia for minor urological surgical procedures
Subject(s)
Benzodiazepines/blood , Flumazenil , Anesthesia, Intravenous/methods , Propofol , MidazolamABSTRACT
This is a study of the acceptability, side effects and value of two injectable contraceptives: Lynoestrenol phenyl propionante and Norethisterone enanthale in 181 fertile women. The first preparation was injected monthly in 65 women for 442 cycles and the second was given every 12 weeks in 89 women, for a total of 297 injections. Effects on menstruation and lactation were observed and the side effects were recorded. Their contraceptive value in 68.9 woman years was studied. The second preparation was better as a contraceptive but caused much more frequent and serious side-effects than the first