Establishment of normal baseline values of blood chemistry in Egyptian fertile women during the child bearing period

In this work the results of external and internal quality control of our laboratory were evaluated. The day to day quality control and external quality control results obtained were quite satisfactory. The working conditions in our laboratory were studied. Seven days storage in deep freeze had an insignificant effect on the results except for alkaline phosphatase. The precision, accuracy and linearity of the MT11 apparatus were checked. The normal range for ambulant healthy females for blood parameters was established. It proved to be within the limits of the international range

study of injectable contraceptives

This is a study of the acceptability, side effects and value of two injectable contraceptives: Lynoestrenol phenyl propionante and Norethisterone enanthale in 181 fertile women. The first preparation was injected monthly in 65 women for 442 cycles and the second was given every 12 weeks in 89 women, for a total of 297 injections. Effects on menstruation and lactation were observed and the side effects were recorded. Their contraceptive value in 68.9 woman years was studied. The second preparation was better as a contraceptive but caused much more frequent and serious side-effects than the first

study of the injectable contraceptive "deladroxate"

A combination of 150 mgm. dihydroxy progesterone acetophenide and 10 mgm, estradiol enanthate was given interamuscularly, at monthly intervals to 31 highly fertile women, for 481 cycles. Clinical and laboratory evaluation were carried out. The combination proved to be an effective and acceptable contraceptive. Not a single pregnancy was encountered during medication. Side effects and menstrual abnormalities were well tolerated and were not substantial causes for dropouts. There were about 1980 blood tests done through the trial to study any change in the haematologic picture, liver function or blood chemistry, with no significant abnormality

Evaluation of a new oral contraceptive [SH. 70850]

A new contraceptive drug containing rgesterel as the prgestatinal gent was tried in 50 women chosen at random for periods varying from 9-10 months. Side effects and endometrial changes were studied and the results discussed

Ophthalmologic studies under the effect of oral contraceptives

Eleven cases of short-term Anorlar 1 users [age 20-30 years] and 22 of the long-term pill users [up to four years] with an age ranging from 30 to 40 years were examined in the Ophthalmology department for ritual acuity, tension of the eye and fundus examination. All cases showed normal tension of the eye and no pathological findings were found in the fundus pictures of these pill users, even up to four years of intake. The defects in visual acuity was not related to the pill intake as they could be explained by the errors of refraction

Study of blood lipids under the effect of oral contraceptives

Serum cholesterol and beta lipoproteins were studied after the intake of Anovlar and Anovlar 1 tablets for short duration [six months] and long duration [2 to 10 years]. There was a significant increase in total serum cholesterol and in beta [atherogenic] lipoproteins, more marked in the long-term users. The state of hyperlipaemia induced by the combined pills can play a role in the pathogenesis of venous thrombosis, either by accelerating clotting or by inhibiting fibrinolysis

Study of liver function tests under the effect of oral contraceptives

A battary of liver function tests were done for a group of normal [30 cases]. Anovlar 1 tablets were given for 20 cases and the tests repeated and there was a significant increase in serum transaminases, zinc and thymol turbidity tests but no change was found in the serum alkaline phosphatase.. A group of long-term users [30 women] were also investigated for this liver functions and there wrre no significant changes in the values of these tests, this reversibility of the liver function could be explained by the phenomenon of "adaptation"

Study of the effect of oral contraceptives on blood coagulation factors

Blood coagulation factors, I, II, VII, VIII and X were assayed before and after the intake of Anovlar 1 tablets for six months and also after the long-term use of Anovlar and Anovlar 1 tables for 2 to 10 year. In both group there was a significant increase in Factors I, II, VII and X. Factors VIII [antihaemphilia globulin] showed no significant change in the studied groups

Electro-gardiographic studies under the effect of combined pills

Seven cases of short-term pill users and 13 of long-term users of combined oestrogen-progestogen combination were studied by ECG tracings. There was no pathological changes in the ECG for the studied cases even after ten years of intake of the pills. This excludes abnormalities in the vascular, myocardial and conduction system of the heart

Fibrinolytic activity under the effect of oral contraceptives

Twenty women were given Anovlar 1 tablets cyclically for six months, and the fibrinolytic activity of their plasma was studied by the euglobulin clot lysis time. Pre-intake study was done for 30 women, and for another group of long-term users of Anovlar and Anovlar 1 tablets for 2-10 years. There was a significant shortening in the euglobulin lysis time in the two groups of pill users. This enhanced fibrinolytic activity counter balances the increase in the blood coagulation and thus preventing the occurrence of intravascular thrombosis