ABSTRACT
Drug's dependence is a common and debilitating disorder. These patients interested to herbal therapy. Lack of valid documents about that is an important problem. Portulaca oleracea L. grows almost all points of distribution and areas of Khuzestan in southern Iran as eating vegetables. This plant is an anti-septic, anti-spasmodic, anti-fever, muscle relaxant. Objective this study was evaluated efficacy of Portulaca oleracea L. in comparison with methadone for symptoms' of morphine withdrawal. Aqueous extracts and methadone given to 36 patients with morphine dependency. CINA scales were used by days 0, 2, 5, 7 and 10 for evaluation. In two groups withdrawal symptoms controlled good and behavior treatment in two groups was similar. The aqueous extract of Portulaca oleracea L. can be as effective in controlling withdrawal symptoms