ABSTRACT
Background: Hypertension is a health problem and alternative medicine is offered for its controlling
Objective: Nutritional effects of Lavandula angustifolia L. [lavender] oil on high blood pressure [BP], and histological changes of the aorta in rat has been investigated in this study
Methods: Therty five male wistar rats were divided into 5 groups; normal, hypertensive and control. Hypertension was induced by daily L-NAME administration in drinking water for 6 weeks and lavender oil [500 mg/kg] or its vehicle was given orally simultaneously. After basal BP measurement, lavender [50 mg/kg, iv] was injected in control groups. Histological evaluation of the thoracic aorta included staining with hematoxylin-eosin and orcein methods
Results: Hypertension induction increased mean arterial BP from 106 to 177 mm Hg and lavender treatment reduced it to 140 mm Hg [P< 0.001]. Lavender had no effect on normal rats. Intravenous injection of lavender reduced BP about 75% in normotensive and hypertensive rats [P<0.001]. Hypertension induction increased cross-section area, aorta and media thickness, and reduced elastic lamina thickness [P<0.001]. Lavender treatment reduced cross-section area of the aorta and media thickness, and increased elastic lamina thickness [P < 0.05]. Hypertension and treatment had no effect on advanthia and elastic lamina numbers.
Conclusion: Nutritional lavender oil prevented BP increases and pathological changes of the aorta in hypertensive rats. It seems lavender oil is beneficial for prophylaxis of hypertension
ABSTRACT
More than 70% of serotonergic neurons have concentrated in raphe nuclei. Raphe nuclei have rested in a rostrocaudal arrangment. They are a neuronal assembling that have joined to gether in midline and appears raphe.To cosideration of important role of serotonin in vital activity, it is necessary that become clear; how is forming the raphe nuclei. Because of resembling between the rat's raphe nuclei and these nuclei in human, the manner of raphe nuclei birth was examined. The 5 embryo of albino rat in 14, 16, 18 and 19 days gestation after sending out of uterus were fixed with boins solution and stained with Kluver and Barrera method. The samples were cutted and evaluated with light microscope. Histological findings showed that in 14[th] day of gestation, two cell groups formed symmetrically; superior [rostral] and inferior [caudal] groups. Rostral cells produce dorsal, median, pontis and magnus raphe nuclei. Caudal cells are the origin of pallidus, obscurus, and magnus raphe nuclei