ABSTRACT
No abstract available.
ABSTRACT
No abstract available.
ABSTRACT
Non-melanoma skin cancer in a psoriasis patient is known to be associated with the treatments for psoriasis such as long-term use of PUVA and cyclosporine rather than the psoriasis itself. We report here on a case of double primary squamous cell carcinoma and acanthosis on a patient who had no history of oral steroid and cyclosporine management. A 44 years old male patient presented for ulcerative skin lesion on both soles. He underwent an operation of wide excision and reconstruction for two separated malignant lesions with using a free flap and skin graft, respectively. Another skin lesion was found on his finger during the follow-up period and excisional biopsy was performed. No evidence of recurrence or metastasis of the squamous carcinoma was found during 2 years follow-up. The excisional biopsy done on his finger was revealed to be acanthosis and no further surgical intervention was needed. This case has an implication that physicians should consider the possibility of multiple skin cancers in a psoriasis patient irrespective of having received immunosuppression therapy, and physicians should try to make an early diagnosis to minimize the patient's morbidity and mortality.
Subject(s)
Humans , Male , Biopsy , Carcinoma, Squamous Cell , Cyclosporine , Early Diagnosis , Fingers , Follow-Up Studies , Free Tissue Flaps , Immunosuppression Therapy , Neoplasm Metastasis , Psoriasis , Recurrence , Skin , Skin Neoplasms , Transplants , UlcerABSTRACT
A poroma is usually described as a benign neoplasm arising from ductal epithelium of eccrine gland. However, in recent years there have been several reports on poromas featuring with combined sebaceous, follicular, and ductal differentiation, and thus establishment of this separate disease entity, "apocrine poroma" may well be justified considering the common embryologic origin of folliculosebaceous-apocrine unit. In our case, the tumor presented as a dark red nodule on the pubic area, being revealed as poroid neoplasm with folliculosebaceous components embedded in the lobules. Immunohistochemically, poroid cells stained with lysozyme. Taking the immunohistochemical staining results as well as the histopathologic findings of folliculosebaceous differentiation into consideration, we have concluded that this tumor is a case of an "apocrine poroma".
Subject(s)
Eccrine Glands , Epithelium , Muramidase , PoromaABSTRACT
BACKGROUND: The measurement of the hardness of a skin lesion is an important component of cutaneous examination in evaluating the progression of diseases such as scleroderma. Current methods to assess hardness have not gained wide acceptance because they tend to be cumbersome, time consuming, and costly. OBJECTIVE: The purpose of this study was to obtain the normal range of skin hardness according to anatomical sites, age groups and sex, and to show the differences among them. METHODS: Ten different anatomical locations of 123 normal Korean individuals (61 males and 62 females) were measured with a durometer. RESULTS: 1. Skin hardness between the two sexes showed significant difference in extensor upper arm, extensor forearm, back, posterior thigh and calf. Excluding the extensor upper arm, male skin was generally harder than female. Shin and calf were significantly harder and flexor upper arm and abdomen were significantly softer than other areas. 2. The tendency of the hardness was similar in each age group. Shin was significantly harder than all other areas in 11-20, 21-30, and 51-60 age groups. Although flexor upper arm and abdomen showed statistically significant softness in 51-60 and >60 age groups, they tended to be softer than other areas in all age groups. 3. Although statistical significance was not seen among all the age groups, age group <11 tended to be harder than other age groups in flexor upper arm, extensor upper arm, flexor forearm and abdomen. CONCLUSION: Skin hardness measured with a durometer showed variation according to sex, age and location. The durometer is an effective, reliable and easy tool especially for the follow-up of the changes in skin hardness in an individual.
Subject(s)
Female , Humans , Male , Abdomen , Arm , Forearm , Hardness , Reference Values , Skin , ThighABSTRACT
There are few reports about generalized hypertrichosis after treatment with topical minoxidil , even though there are numerous reports about generalized hypertrichosis after treatment with oral minoxidil. We experienced a rare case of generalized hypertrichosis after treatment with 3% topical minoxidil in a 5-year-old boy. He visited our hospital for generalized hypertrichosis on face, trunk, arm after treatment with 3% topical minoxidil for 2 months due to alopecia areata. The laboratory examination including CBC, SMA and the level of corticotropin releasing hormone, luteinizing hormone, follicular stimulating hormone, cortisol, estradiol, testosterone were within normal limits. Two months after discontinuation of treatment with 3% topical minoxidil, the hair started to shed and six months after discontinuation of topical minoxidil, he showed almost complete resolution.
Subject(s)
Child, Preschool , Humans , Male , Alopecia Areata , Arm , Corticotropin-Releasing Hormone , Estradiol , Hair , Hydrocortisone , Hypertrichosis , Luteinizing Hormone , Minoxidil , TestosteroneABSTRACT
Unilateral localized hyperhidrosis over scalp and face is an extremely rare disease that usually has undetermined origin. We report a case of idiopathic unilateral localized hyperhidrosis over left scalp and face. A 55-year-old female patient with unilateral hyperhidrosis that is localized in the left side of scalp and face visited our dermatology clinic. She had increased sweating in left face and scalp, recurring in summer for 3 years. She complained of the exacerbation by thermal and gustatory stimuli and exercise. The starch iodine test and digital infrared thermal imaging test revealed a marked increase in sweat gland activity on the affected areas as compared to the contralateral normal sites.
Subject(s)
Female , Humans , Middle Aged , Dermatology , Hyperhidrosis , Iodine , Rare Diseases , Scalp , Starch , Sweat , Sweat Glands , SweatingABSTRACT
Acrodermatitis enteropathica is a rare autosomal recessive disorder characterized by alopecia, acral and periorificial dermatitis and diarrhea. True acrodermatits enteropathica requires lifelong zinc replacement whereas transient acrodermatitis enteropathica, an acquired disorder with identical clinical features, requires only transient zinc replacement. Although premature and milk-fed infants are particularly vulnerable to development of both conditions, there have been some reports of acrodermatitis enteropathica in full-term breast-fed infants. We report a case of transient acrodermatitis enteropathica in a 5-month-old, full-term, breast-fed male baby with identical history in his 2 elder siblings. The patient presented with a 5-month history of diarrhea, hair loss and crusted erythematous patches on periorificial areas, and fingers and toes. His serum zinc levels were within lower normal limits in 2 consecutive tests. His mother was also checked for zinc levels, which was normal in serum but was markedly reduced in breast milk. Diarrhea and skin lesions disappeared promptly with oral zinc supplementation and did not recur after 11 weeks of treatment.
Subject(s)
Humans , Infant , Male , Acrodermatitis , Alopecia , Dermatitis , Diarrhea , Fingers , Hair , Milk, Human , Mothers , Siblings , Skin , Toes , ZincABSTRACT
Nevus lipomatosus cutaneous superficialis(NLCS) is a rare nevoid anomaly characterized by ectopic adipose tissue in the dermis. In this disease, two clinical types are distinguished: the classical type consisting of grouped papules and nodules, which are distributed linearly over the buttocks or upper thighs, and solitary type consisting of solitary pedunculated or dome-shape nodule without predilection. The solitary type is much rarer than the classical type. Unlike the classical type, the solitary type, especially on the forehead, is often mistaken for another type of benign tumor such as a lipoma. The author experienced a case of solitary NLCS, a 56-year-old female who had flesh, soft and edematous plaque on the forehead with soft surface during 13 months. Histological examination showed ectopic mature adipocytes in the dermis. The lesion was treated by surgical excision.
Subject(s)
Female , Humans , Middle Aged , Adipocytes , Adipose Tissue , Buttocks , Dermis , Forehead , Lipoma , Nevus , ThighABSTRACT
Blue nevus is a dermal melanocytic disorder, and there are two types of blue nevi are generally recognized; the common blue nevus and the cellular blue nevus. Although cellular blue nevus might show malignant transformation in rare cases, common blue nevus is considered completely benign. We report a case of common blue nevus with clinical indicators of malignant change, the loss of regular border and the development of satellite lesions, but showing histopathologically benign finding. A 29-year-old male patient with blue-black colored, 1cmx1cm sized nodule on right hand dorsum is presented. This lesion had been presented for at least 7 years, but it began to grow with irregular border and some satellite lesions from about 5 months ago. Under the impression of malignant blue nevus, a biopsy was performed. The histopathological examination showed that the nevus cells were dispersed in the papillary and reticular dermis, without any malignant changes.