ABSTRACT
Aim: Since the impact of H. pylori and its virulence is not clear in GERD, this study aimed to evaluate the prevalence of cag A and cag E gens of H. pylori among Iranian GERD patients
Background: Gastroesophageal reflux disease [GERD] is defined as a condition of reflux the stomach juice by low pH causes tissue damage. Helicobacter pylori may or may not influence the GERD; however, it is unclear
Methods: This study was a case-control study performed on patients with GERD who underwent upper gastrointestinal endoscopy at Taleghani Hospital of Tehran, Iran. Prevalence of H. pylori and presence of the cag A and cag E genes in GERD and control group was investigated
Results: H. pylori was detected in 54% and 62% of GERD and control groups respectively. Prevalence of cag A gene among GERD patients was 44.4% whereas among the control group it was 87%. Prevalence of the cag E among GERD patients and control group was 44.4% and 64% respectively. Coexistence of cag A and cag E in GERD patients was 25.7% and in the control patients it was 54.8%
Conclusion: We did not find correlation between H. pylori existence in GERD patients in comparison to the control group. Similar to other Asian studies, the presence of the cag A in control group was more than GERD patients significantly. The co-existence of cag A and cag E was also more in control group significantly
ABSTRACT
Background and study aims: In Iran, the epidemiology of primary sclerosing cholangitis [PSC] and its association with inflammatory bowel disease [IBD] have not been studied thoroughly. This study investigates the epidemiology and prevalence of IBD among patients with PSC
Patients and methods: A retrospective study of 154 patients with PSC was conducted. The demographic and clinical data were collected, and the variables were analysed in the following two patient groups: patients with both PSC and IBD, and patients with PSC and without IBD
Results: A total of 154 patients with a mean age of 40.3 years [range 20-81 years] were included, of whom 57 [37%] were female and 97 [63%] male. Ninety-six patients [62.3%] were diagnosed with IBD, 92 [59.7%] with ulcerative colitis, and four [2.6%] with Crohn's disease. In this study, elevated alkaline phosphatase levels were found in 90.8% of patients. The intra-hepatic duct [IHD] and extrahepatic duct [EHD] were involved in 70.5% of patients, isolated intrahepatic bile duct in 24.4%, and isolated extrahepatic duct in 3.8%. Small-duct PSC [normal results of imaging and PSC proved by histology of liver biopsy] was observed only in 1.3% of patients
Conclusion: PSC has become increasingly diagnosed in Iran. This is possibly because of better diagnostics and the increasing prevalence of IBD in this country. For diagnosing PSC and identifying the presence of IHD strictures, the results of both magnetic resonance cholangiopancreatography [MRCP] and endoscopic retrograde cholangiopancreatography [ERCP] showed good interobserver agreement, but the ERCP results could be used to evaluate the presence and severity of EHD strictures