study of verapamil on morphive dependent animals

The effects of verapamil on naloxone precipitated effects of morphine-dependent guinea pigs ileum were studied in vitro. Dependence was produced in experimental animals by repeated administration of morphine for 15 days. Non-dependent animals given saline for the same period were taken as controls. Verapamil effectively blocked the naloxone induced contractions in ileal strips of morphine-dependent animals. These observations on animal tissues are significant and may suggest clinical usefulness of verapamil in the management of morphine-dependent patients