Diagnositic and Prognoistic values of serum CEA and CA19-9 levels in Periampullary Cancer / 한국간담췌외과학회지

PURPOSE: The value of carcinoembryonic antigen(CEA) and carbohydrate antigen 19-9(CA19-9) in periampullary cancers have not been clearly established. Diagnostic and prognostic values of these two markers in resectable periampullary cancer were clarified in this study. METHODS: Preoperative serum levels of CEA and CA19-9, and clinicopathologic features were reviewed in 151 surgical patients with periampullary cancer who were admitted in department of General Surgery of Seoul National University Hospital from Feb. 1996 to Dec. 2000. Postoperative serum levels of these tumor markers were also reviewed. For comparison with benign disease, preoperative serum levels of these tumor markers in GB stone patients were reviewed. After resection, serial tumor markers had been followed up. Disease recurrence was confirmed by imaging study. RESULTS: The CA19-9 concentration was above the cut-off limit (37U/ml) in 60.8% and the CEA concentration was above the cut-off limit(5ng/ml) in 10.5% of the periampullary cancer. Preoperative serum CEA and CA19-9 did not demonstrate the TMN stage, pathologic differentiation and the tumor size. The difference between the survival curves of the preoperative serum CA19-9 level (cut-off 100U/ml) was highly significant (p<0.05) in ampullary cancer. After curative resection, the serum CEA and CA19-9 level were decreased below cut-off level (5ng/mg in CEA, 37U/ml in CA19-9) in 55.6% and 71.2% of total periampullary cancer patients respectively. The mean survival period of the group with normalized CA19-9 level after surgery was significantly longer than that of the group with persistent elevated serum CA19-9 level (52.18 vs 21month, p<0.005) in ampullary cancer. The recurrent sensitivities of the CA19-9 were 57%, 50%, 67% in ampullary cancer cancer, distal CBD cancer, pancreatic head cancer respectively. CONCLUSION: Serial check of serum levels of the CA19-9, CEA is useful in diagnosis and recurrence detection in periampullary cancer.

Reactive oxygen intermediate production of phagocytes from human cord blood / 대한면역학회지

No abstract available.

Concentrations of lead, iron and zinc in blood of coal workers' pneumoconiosis patients / 예방의학회지

Lead, iron, and zinc concentrations in whole blood were determined by atomic absorption spectrophotometry, using a simple one-step dilution procedure, which were measured in 3 groups, 98 officers unexposed to dust or to metal, 58 coal miners without pneumoconiosis, and 113 coal workers' pneumoconiosis (CWP) patients. The results were as follows; 1. The precisions (C. V.%) of lead, iron, and zinc in blood were 12.65+/-6.95%, 1.47+/-1.25% and 6.35+/-3.34%, respectively. 2. Lead and zinc in blood showed the log-normal distribution unlike iron in blood which showed normal distribution. 3. Lead, iron, and zinc concentrations in blood of 3 groups were follows. There was significant difference of concentration far zinc in blood by groups statistically. 4. The difference of lead, iron, and zinc concentrations in blood was not significant (p>0.05) by profusion on chest radiographs.

Quantitative Analysis of Quartz, Mica, and Feldspar in Respirable Coalmine Dust in Taebaek Area by Fourier Transform Infrared Spectrophotometry / 예방의학회지

A Fourier transform infrared spectrophotometric method was described for the determination of quartz, mica(sericite) and feldspar(potassium feldspar) in respirable dust in Taebaek area. The results were as follows; 1) The concentration of minerals were determined from the intensity of absorption peak of quartz at 799 cm-1, sericite at 539 cm-1, and potassium feldspar at 648 cm-1 respectively. 2) The precision(C. V. %) for the quartz determination was 7.70+/-2.68 % from 10 to 200 microgram of quartz. 3) The precision for the sericite determination was 16.34+/-6.82 % from 30 to 500 microgram of serictite. 4) The precision for the potassium feldspar determination was 5.28+/-1.74 % from 30 to 500 microgram of potassium feldspar. 5) The concentration of respirable dust in Taebaek area was 4.90+/-3.29 mg/m3(0.4-93.7%), percent quartz was 1.80+/-4.14% (0.01-20.56%), percent sericite was 11.37+/-6.43% (0.00-29.69%), percent potassium feldspar was 8.15 % (n=7, 3.41-19.70%). 6) The difference of respirable coal dust, quartz, and sericite concentration in drilling, coal cutting, hauling and separating was significant respectively (p<0.05).

Quartz Concentration and Respirable Dust of Coal Mines in Taeback and Kangneung Areas / 예방의학회지

In order to investigate working conditions of underground coal mines, this work was undertaken to evaluate the respirable dust and the concentration of quartz in Taeback and Kangneung areas. The concentration of quartz was determined by Fourier Transform Infrared Spectrophotometry. The results were as follows; 1) The concentration of respirable dust of drilling and coal face in Taeback and Kangneung areas were as followed. 2) Distribution of respirable dust was well fitted to the long-normal distribution and geometric mean value was log(-1) 0.37+/-log(-1) 0.47 (2.34+/-2.95) mg/m3. 3) The difference of respirable dust concentrations in Taeback and Kangneung areas was not significant statistically (p>0.05). 4) The concentration of quartz of drilling and coal face in Taeback and Kangneung areas were as followed. 5) Distribution of quartz concentrations was well fitted to the log-normal distribution and geometric mean value was log(-1) 0.33+/-log(-1) 0.45 (2.14+/-2.82)%. 6) The difference of quartz concentrations in Taeback and Kangneung areas was not significant (p>0.05), but significant at drilling sites and coal faces (p<0.05).