Effects of Diltiazem on Mean Arterial Pressure and Heart Rate during Tracheal Extubation in Hypertensive Patients / 대한마취과학회지

BACKGROUND: Tracheal extubation provokes hypertension and tachycardia, as does tracheal intubation. Especially hypertensive patients are more likely to exhibit substantial fluctuations in hemodynamics and myocardial ischemia than normotensive patients during these stressful periods. The aim of present study was to evaluate the effects of intravenous diltiazem in attenuating mean arterial pressure(MAP) and heart rate(HR) responses to tracheal extubation in hypertensive patients. METHODS: Thirty-seven hypertensive patients who were to undergo elective surgery were randomly assigned to one of three groups : saline (control), lidocaine 1 mg/kg, and diltiazem 0.2 mg/kg. These drugs were given 2 minutes prior to tracheal extubation. Anesthesia was induced by the injection of fentanyl 1.5 microgram/kg, thiopental 5 mg/kg, and vecuronium 0.1 mg/kg and maintained with 50% N2O in O2 and 1~2 vol.% enflurane. Changes in HR and MAP were measured during and after tracheal extubation. RESULTS: In the diltiazem group, the MAP decreased significantly at drug administration, extubation, and post-extubation 1 min. However there were no significant differences in HR among 3 groups. CONCLUSIONS: These data suggest that intravenous injection of diltiazem 0.2 mg/kg given 2 minutes before tracheal extubation was effective in attenuating MAP changes associated with tracheal extubation. But HR changes were not different significantly among 3 groups. Further studies are required for the effective prophylaxis against tachycardia associated with tracheal extubation.

Patient-Controlled Epidural Analgesia during Labor and Delivery / 대한마취과학회지

BACKGROUND: Epidural administration of dilute solution of local anesthetic and lipid-soluble opioid provides the best pain relief during labor and delivery. The purpose of this study was to evaluate the safety, efficacy and patient satisfaction of patient-controlled epidural analgesia compared with continuous infusion epidural analgesia. METHODS: Forty healthy full-term parturients who requested epidural analgesia were assigned randomly to either patient-controlled epidural analgesia (PCEA) group or continuous infusion epidural analgesia (CIEA) group. All parturients received proper dose of 0.25% bupivacaine with 0.0008% fentanyl to block T10 sensory level. PCEA was programmed as followings; no background infusion, a 4 ml bolus dose and 15min lock-out interval using 0.0625% bupivacaine with 0.0002% fentanyl. CIEA was started with the same solution at 12ml/hr constantly. RESULTS: Hourly requirement of 0.0625% bupivacaine (mean+/-SD 7.1+/-5.8 ml/hr, median 7.6 ml/hr in PCEA group and mean+/-SD 13.2+/-2.9 ml/hr, median 12 ml/hr in CIEA group) during labor was significantly reduced in PCEA group (p<0.05). Maternal satisfaction, obstetric and neonatal parameters were shown no statistically significant difference. Incidences of postpartum complications such as gait disturbance, urinary difficulty, pruritus, nausea and vomiting were rare in both groups. CONCLUSIONS: Patient-controlled epidural analgesia is safe and effective and has 37% sparing effect of bupivacaine dosage used per hour compared with continuous infusion epidural analgesia.