ABSTRACT
Background: Upper Gastrointestinal bleeding [GI] bleeding can be a fatal and life threatening emergency and need emergency treatment to avoid unwanted morbidity and mortality
Objective: To determine the efficacy of Terlipressin in cases of upper GI bleeding due to liver cirrhosis
Methodology: In this case series, there were total 50 cases of upper GI bleed within last 24 hours due to liver cirrhosis of both genders, falling in the age range of 30-70 years, presenting to medical wards and emergency department. Terlipressin was injected in a dose of 1mg every 6 hour. This therapy was given for maximum of 72 hours. The efficacy was labeled as yes when there was no bleeding episode over 12 hours. Data was entered and analyzed by sing SPSS version 21
Results: In this study, there were total 50 cases out of which 35 [70%] were males and 15 [30%] females. The mean age and duration of cirrhosis were 49.45+/-6.85 years and 4.87+/-2 years respectively. The efficacy was almost equal in both genders [p= 0.95]. The efficacy was slight better in age group 30-49 years where 16 [69.56%] out of 23 cases had it [p= 0.12]. The efficacy was significantly better in Class A where 4 [80%] out of 5 cases had it as compared to Class B and C with p= 0.01
Conclusion: Terlipressin has good efficacy in treating upper GI bleed in cases with liver cirrhosis and this is significantly better in cases with Child Pugh Class A