ABSTRACT
<p><b>OBJECTIVE</b>To study the application of cluster analysis in micrangium detection in malignant nasal and paranasal sinus tumor.</p><p><b>METHODS</b>Microvessel density (MVD) counting and cluster analysis were used to detect the micrangium in patients with malignant nasal and paranasal sinus tumor to assess the association between the malignancy and MVD.</p><p><b>RESULTS</b>According to cluster analysis, the MVD counting could be clustered into two groups, and the MVD showed significant differences between the tumor tissues, adjacent normal tissue and the control group (P<0.01), a result consistent with that by analysis of variance of the MVD.</p><p><b>CONCLUSION</b>Cluster analysis can be used in clustering of MVD counting in malignant nasal and paranasal sinus tumor to simplify MVD counting, and offers an important analytic method for micrangium analysis in tumors.</p>