Effect of testosterone propionate and oestradiol benzoate on aggressive behaviour of mice

As testosterone, which is aromatized in the brain to oestradiol, can increase aggressive behaviour in male mice, it was claimed that oestradiol modulates aggressive behaviour. The effect of testosterone propionate and oestradiol benzoate on aggressive behaviour of mice and the need of early exposure to the hormone to express the behaviour was investigated in the present work. It was found that testosterone propionate could signficantly increase aggressive behaviour of adult castrated male mice while oestradiol benzoate had no effect on aggressive behaviour of adult male or female mice whether animals were intact or gonadectomized. Testosterone propionate could increase significantly aggressive behaviour in adult male or female mice that were treated with a primary dose of the hormone in the third day of life while it was devoid of any effect in animals that were not exposed to the hormone. It could be concluded that testosterone propionate and oestradiol, has an activational effect on aggressive behaviour of mice that were primed [organized] early in life with the hormone

Glaucoma a clinico-experimental study of the effect of interaction of some anti-glaucoma drugs on the intraocular pressure

Many drugs are used in the management of glaucoma, each exerting its effect through a certain mechanism. The interaction of two or more of these drugs administered concomittently is of importance to the ophthalmologist. Such interaction may reduce the intraocular pressure [IOP], or may antagonize the intended therapeutic effect of any of them. The effect of pilocarpine, timolol, eserine and diamox, each alone and in different combinations was studied clinically in 149 eyes of chronic simple glaucoma, and experimentally in albino rabbits. The results showed that pilocarpine remains the most effective and safest topical drug for prolonged use in open angle glaucoma. The use of timolol is accompanied by two phenomena "the short term escape" and the "long term drift". Combining it with another drug after one year of its use is essential to keep its efficiency. Pilocarpine-acetazolamide is the most effective combination in reducing IOP compared to all other combinations