ABSTRACT
The clinical manifestations of neurosystemic autoimmunity diseases are complicated and varied. Symptoms of different diseases often overlap and are not easily identified. It is very important to detect autoantibodies in serum and(or) cerebrospinal fluid for diagnosis, differential diagnosis, treatment and prediction of disease. With advances in autoantibody detection, multi-method and multi-index joint detection strategies, the results of which can provide more comprehensive disease information than single indicator detection and make diagnosis and treatment of disease more quickly and accurately, are widely used. Over the past decade, a series of pathogenic autoantibodies were identified. The discovery of these autoantibodies led to the diagnosis of many previously undiagnosed diseases. This paper reviews the research progress of autoantibodies associated with neurosystemic autoimmunity diseases, analyzes the current situation of detection in China and puts forward some suggestions in order to provide guidance for basic research and clinical work.