ABSTRACT
Objective:To investigate the clinical significance of early detection of serum procalcitonin in children with hand-foot-and-mouth disease complicated by bacterial infection and provide reference for clinical diagnosis of the disease in children.Methods:A total of 126 children patients with hand-foot-and-mouth disease who received treatment in the First People's Hospital of Taizhou between December 2017 and December 2018 were included in this study. They were assigned into viral plus bacterial infection group and simple viral infection group ( n = 63/group) according to whether they suffered from bacterial infection. An additional 20 healthy children who concurrently received physical examination in the First People's Hospital of Taizhou were included in the control group. Serum levels of interleukin-6, interleukin-10, white blood cell count, C-reactive protein, and procalcitonin were compared among the three groups and bacterial infection was analyzed. Results:Serum levels of interleukin-6, interleukin-10 and C-reactive protein in the simple viral infection group were (3.75 ± 0.76) ng/L, (55.31 ± 11.27) ng/L, (10.91 ± 1.16) mg/L, respectively, which were significantly higher than those in the control group [(1.39 ± 0.41) ng/L, (11.72 ± 9.58) ng/L,(2.16 ± 0.65) ng/L, t = 8.040, 16.982, 7.825, all P < 0.05]. Serum levels of interleukin-6 and interleukin-10 in the bacterial plus viral infection group were (4.10 ± 1.09) ng/L and (66.64 ± 7.42) ng/L, respectively, which were significantly higher than those in the control and simple viral infection groups ( t = 13.088, 9.053, 10.031, 15.021, all P < 0.05). Serum C-reactive protein level in the bacterial plus viral infection group was significantly higher than that in the simple viral infection group [(26.28 ± 4.35) mg/L vs. (10.91 ± 1.16) mg/L, t = 21.938, P < 0.05]. Serum procalcitonin level and white blood cell counts in the bacterial plus viral infection group were (0.63 ± 0.04) μg/L, (15.12 ± 3.97) × 10 9/L, respectively, which were significantly higher than those in the control group [(0.13 ± 0.02) μg/L, (7.93 ± 1.91) × 10 9/L, both P < 0.05] and simple virus infection group [(0.07 ± 0.01) μg/L, (8.78 ± 1.12) × 10 9/L, both P < 0.05]. The infection rates of enterovirus 71 and universal enterovirus in the simple viral infection group were significantly lower than those in the bacterial plus viral infection group ( χ2 = 20.329, 31.924, both P < 0.05). Conclusion:Serum procalcitonin level is highly specific and accurate for the diagnosis of hand-foot-and-mouth disease. Serum procalcitonin level and white blood cell can be used together as a sensitive index to identify whether bacterial infection occurs in children with hand-foot-and-mouth disease.
ABSTRACT
Objective To investigate the clinical effect of ibuprofen on preventing intracranial hemorrhage in premature infants and its influence on the levels of NT-proBNP and ET-1.Methods From January 2016 to December 2017,112 premature infants in Taizhou Hospital were selected as study objects after screening by inclusion and exclusion criteria.The infants were randomly divided into observation group and control group according to the digital table,with 56 cases in each group.The control group was treated with routine therapy,and the observation group was given ibuprofen prophylaxis.The incidence of intracranial hemorrhage,clinical index and serum NT-proBNP,ET-1 levels were compared between the two groups.Results There was significant difference in the incidence rate of intracranial hemorrhage between the observation group (17.86％) and the control group (30.36％)(x2 =12.472,P ＜0.05).The serum levels of NT-proBNP and ET-1 in the observation group were significantly lower than those in the control group(all P ＜ 0.05).There were no statistically significant differences in liver function,renal function,coagulation abnormality and oliguria between the two groups (all P ＞ 0.05).There were no statistically significant differences in feeding intolerance and gastric hemorrhage between the two groups (all P ＞ 0.05).Conclusion The application of ibuprofen suspension can effectively prevent intracranial hemorrhage in premature infants,which is worthy of clinical use.
ABSTRACT
One hundred and fifty eight post-stroke patients in the recovering period were divided into intervention group (78 cases) and control group (80 cases).Patients in intervention group received home rehabilitation service provided by general practitioners (GP) for 6 months,while patients in control group received routine rehabilitation.After 6-months,the scores of self-rated health measurement scale (SRHMS) in intervention group were significantly higher than those of control group (P ＜0.01);the visiting time and frequency,medical costs and time of caregiving were decreased (P ＜ 0.01);and the satisfaction score of the patients in intervention group was 97％.The results show that home rehabilitation service can improve effectiveness of rehabilitation for post-stroke patient in recovering period.