ABSTRACT
Objective To evaluate the value of transrectal real-time tissue elastography (TRTE) combined with multi parameter magnetic resonance imaging (MRI) in prostate biopsy.Methods One hundred and five patients of suspected prostate cancer patients were treated from December 2013 to December 2015 in Jiaxing Traditional Chinese Medicine Hospital. All the patients were confirmed by operation and pathology. Transrectal ultrasonography guided biopsy was performed in 105 patients after TRTE and MRI examinations, respectively, including routine 6 point needle biopsy and targeted biopsy of the positive area. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of TRTE, MRI and TRTE combined with MRI guided biopsy in the diagnosis of prostate cancer were evaluated with the results of operation and pathology as the gold standard.Results Surgical pathology confirmed that there were 44 benign prostatic nodules and 61 cases of prostate cancer in 105 cases. Fifty-two cases of prostate cancer was diagnosed by TRTE, and 45 cases were confirmed by operation and pathology. Fifty-six cases of prostate cancer was diagnosed by MRI, and 48 cases were confirmed by operation and pathology. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of diagnosing prostate cancer by TRTE, MRI and TRTE combined with MRI guided percutaneous biopsy were 71.4％, 84.0％, 78.0％, 0.865, 0.698, 78.6％, 81.8％, 80.0％, 0.857, 0.734, 90.1％, 88.6％, 89.5％,0. 916 and 0.866. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of diagnosing prostate cancer by TRTE combined with MRI guided biopsy were higher than those of TRTE and MRI. Conclusions Both TRTE and MRI have their respective advantages. The accurate localization before puncture is helpful to develop individualized program for prostate puncture, and the combining use of the two methods can improve the detection rate of prostate cancer.