Association between HBeAg-negative chronic hepatitis B and preC/BCP mutation / 临床肝胆病杂志

Studies on the HBV gene have shown that HBeAg-negative chronic hepatitis B (CHB) is associated with gene mutations in the pre-C (preC) and basic core promoter (BCP) region of HBV DNA, and it is pointed out that the mutation in the preC/BCP region can affect the expression of serum HBeAg and is closely associated with the low replication of HBV DNA in the body, the progression of diseases, and the response to antiviral therapy, which makes the treatment of CHB more complicated. This article reviews the current status of the treatment of HBeAg-negative CHB, structure and mutation of HBV preC/BCP region, and the influence of mutation on the progression of HBeAg-negative CHB and the effect of antiviral therapy for hepatitis B.