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Objective To investigate the clinical significance of ECG QRS wave extension of the time limit for heart failure patients.Methods A retrospective analysis of heart failure patients electrocardiogram QRS complex duration and ultrasound heartbeat graph parameters were conducted,and according to the ECG QRS complex duration the patients were divided into QRS ≥ 120ms group and Q RS ＜ 120ms group,The cardiac functional grading,ultrasound heartbeat graph parameters,incidence rate of malignant arrhythmia,mortality within 1 year were compared between the two groups,in order to explore the possibility of QRS complex duration and the United States of America New York Heart Association(NYHA) classification of cardiac function,left ventricular end diastolic diameter(LVEDd),left ventricular ejection fraction(LVEF),left ventricular fraction shortening(LVFS),malignant arrhythmia incidence,mortality.Results No significant difference was found in the cardiac function between QRS ≥ 120ms group and QRS ＜120ms group(t =0.00,0.10,0.11,all P ＞ 0.05).LVEDd of ECG QRS complex duration ≥ 120ms group was significantly higher than that of ECG QRS complex duration ＜ 120ms group (t =3.31,P ＜ 0.05).In addition,LVFS value and LVEF value of ECG QRS complex duration≥ 120ms group were significantly lower than those of ECG QRS complex duration ＜ 120ms group (t =17.05,3.54,all P ＜0.05).However,LAD between the two groups had no significant difference(t =0.09,P ＞ 0.05).40 cases in ECG QRS complex duration ≥ 120ms group,8 cases had malignant arrhythmia in the hospital,6 cases of cardiac death,2 patients died of pulmonary infection.In ECG QRS complex duration ＜ 120ms group,4 cases had malignant arrhythmia during hospitalization,3 cases of cardiac death,1 cases died of septic shock.The incidence rate of malignant arrhythmia and mortality within 1 year of ECG QRS complex duration ≥120ms group were significantly higher than those of ECG QRS complex duration ＜ 120ms group (x2 =4.01,P ＜0.05).In the ECG QRS complex duration ≥ 120ms group,LVEDd of 6 cardiac death patients was higher than 70mm,LVEF was less than 30％.Conclusion Wave duration ≥ 120ms has nothing to do with the cardiac function grade,gender,age,heart failure,but relate with the incidence rate of malignant arrhythmia and mortality within 1 year,which can be used to evaluate disease severity and prognosis.
ABSTRACT
Glycoprotein (GP) IIb/IIIa is an important index for assessing the function of platelets. To investigate the effects of Honghua Injection, a Chinese patent medicine made from extracts of Carthamus tinctorius L, on GP IIb/IIIa is a key study in evaluating the inhibition properties of Honghua Injection on platelet aggregation.
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Objective To analyze the incidence of cerebral vasospasm (CVS) in patients with traumatic subarachnoid hemorrhage(t-SAH), time windows of CVS as well as the risk factors. Method A total of 98 patients,with t -SAH admitted from June 2007 to December 2008, were enrolled for this prospective study. The hemodynamics of middle cerebral artery (MCA) in these patients was monitored with trancranial Doppler (TCD) daily for 7 days after admission and on the 14th day of hospital stay. The incidence of cerebral vasospasm (CVS) in patients with traumatic subarachnoid hemorrhage (t-SAH) ,time windows of CVS as well as the risk factors were analyzed. Results Of them, 41 patients (41.8%) had CVS. The flow velocity of MCA in patients with GCS≤ 8 was significantly higher than that in patients with GCS≥9. Classified by t-SAH cumulative blood Hijdra method, 2(4.44%) of 45 patients(45.9%)with scores 6 or less,9 (29.0%)of 31 patients (37.8%) with scores 6～ 13,and 8 (36.4%) of 22 patients (20.0%)with scores 13 or more had CVS. Severe CVS occurred in 13 (35. 1% )of 37 surgical patients (37.8%), and local cerebral infarction occurred in four surgical patients after symptomatic treatment. The flow velocity of the MCA was significantly higher in surgical patients than that in non-surgical patients 3 days after admission. Conclusions The severity of original trauma, bleeding, location of t-SAH and operation are the major risk factors to lead to CVS in patients with t-SAH. Attention should he paid to those risk factors during the treatment of patients with t-SAH.
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Objective To study the relationship between single nucleotide polymorphisms(SNPs)of thrombospondin-1 gene(TSP-1)and coronary artery disease(CAD).Methods Fragment 8831A→G of Exon thirteen in TSP-1 gene from 437 cases of CAD and 423 subjects without coronary heart disease from November 2003 to May 2007 in The First Affiliated Hospital of Nanjing Medical University and Affiliated Yueyang Hospital of Shanghai Traditional Chinese Medicine University were analysed by polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP),and sequence analysis for confirmation.Results The prevalence of the 8831G in the 860 subjects was rare.No association of the N700S polymorphism with an altered risk of ACS was found in our study (GA VS AA:OR=1.699;95%CI 0.309-9.348,P＞0.05).Conclusion The TSP-1 8831A→G polymorphism is rare and unrelated to CAD in the Chinese Han population.