ABSTRACT
Objective To analyze the curative effect of teprenone capsule combined with quadruple therapy in the treatment of chronic atrophic gastritis.Methods From June 2013 to June 2017,one hundred and fifty patients with chronic atrophic gastritis admitted to the First Hospital of Ninghai County were retrospectively selected.According to different treatment schemes,they were divided into control group and observation group,with 75 patients in each group.The control group was treated with routine quadruple therapy, and the observation group was treated with teprenone capsule combined with quadruple therapy.The effective rate of the two groups was compared.Results The total effective rate of the observation group was 97.33% ,which was higher than 85.33% of the control group,the difference between the two groups was statistically significant(χ2 =3.197,P<0.05).After treatment,the levels of interleukin-8 and tumor necrosis factor - alpha in the observation group were ( 7.04 ± 1.03 ) ng/L, ( 41.02 ± 1.72)ng/L,respectively,which in the control group were (10.81 ± 1.63)ng/L,(57.35 ± 2.95) ng/L,respectively, the differences between the two groups were statistically significant (t=6.028,7.281,all P <0.05).The gastric mucosa score and the gastrin concentration in the observation group were (1.13 ± 0.32)points,(8.97 ± 2.33)pmol/L, respectively,which in the control group were ( 1. 82 ± 0. 61 ) points, ( 5. 36 ± 1. 52 ) pmol/L, respectively, the differences between the two groups were statistically significant ( t =5. 661, 6. 024, all P <0. 05 ). Conclusion Teprenone capsule combined with quadruple therapy can improve the clinical efficacy and reduce the degree of inflammation in patients with chronic atrophic gastritis,which is worthy of clinical application.
ABSTRACT
Objective To compare the application effects of percutaneous tracheotomy and the traditional tracheotomy for patients in ICU. Methods From February 2015 to June 2016,56 patients in ICU of the First Hospital of Ninghai County were selected in the research and randomly divided into two groups according to the digital table, with 28 cases in each group. The traditional group received traditional tracheotomy. The percutaneous group received the percutaneous tracheotomy. The surgical blood loss,operative time,incision length,scar area,incision healing time, mechanical ventilation time,survival rate and incision infection,subcutaneous emphysema,trachea collapse and other complications were compared between the two groups. Results The operative blood loss,operative time,incision length,scar area,incision healing time,mechanical ventilation time in percutaneous group were (3. 14 ± 0. 15) mL, (10. 02 ± 3. 53)min,(1. 52 ± 1. 52)cm,(1. 18 ± 0. 12)cm2 ,(3. 53 ± 0. 44)d,(5. 73 ± 1. 13)d,respectively,which in the control group were (7. 24 ± 1. 91)mL,(30. 98 ± 11. 72)min,(5. 26 ± 5. 26)cm,(5. 72 ± 1. 95)cm2 ,(7. 46 ± 1. 25)d,(5. 67 ± 1. 82) d,respectively,the blood loss,operative time,incision length,operation scar area,incision healing time between the two groups had statistically significant differences (t = 8. 635,8. 052,8. 155,8. 742,9. 251, all P < 0. 05). The survival rate of the two groups was 100. 0％ . The incidence rate of incision infection,subcutaneous emphysema,trachea collapse in the percutaneous group was 17. 86％ ,which was significantly lower than 64. 29％ in the traditional group,the difference was statistically significant(χ2 = 15. 014,P < 0. 05). Conclusion Percutaneous tracheotomy and the traditional tracheotomy have certain effect for patients in ICU,compared with traditional tracheotomy, percutaneous tracheotomy has less blood loss, less operation time, can reduce the complications, and can replace traditional tracheotomy for rescue and treatment for ICU patients.