ABSTRACT
Background: Implantation remains a limiting step in IVF/ICSI. Endometrial injury isa promising procedure aiming at improving the implantation and pregnancy rates after IVF/ICSI
Objective: The aim of this study was to evaluate the effect of endometrial injury induced in precedingcycle on IVF/ICSI outcome
Materials and Methods: Four hundred patients undergoing their first IVF/ICSI cycle in two IVF units in Minia, Egypt were randomly selected to undergo either endometrial injury in luteal phase of preceding cycle [intervention group] or no treatment [control group]. Primary outcome wasthe implantation and live birth ratesWhile the secondary outcome was clinical pregnancy, miscarriage, multiple pregnancy rates, pain and bleeding during and after procedure
Results: Implantation and live birth rates were significantly higher in intervention compared with control group [22.4% vs. 18.7%, p=0.02 and 67% vs. 28%, p=0.03], respectively. There was also a significant reduction in miscarriage rate in intervention group [4.8% vs. 19.7%, respectively, p<0.001]
Conclusion: Endometrial injury in preceding cycle improves the implantation rate and live birth rate and reduces the miscarriage rate per clinical pregnancy in patients undergoing their first IVF/ICSI cycle