Expression of kisspeptin in hypothalamus and the relationship between kisspeptin and puberty / 国际儿科学杂志

The priming of puberty is date from the increase of the secretion of hypothalamic gonadotropin-releasing hormone (GnRH). Recently,Kisspeptins/ GPR54 signaling were found critical to promote the secretion of GnRH and the onset of puberty. KISSI expresses in special area of hypothalamus and is regulated by sex steroids in the estrous cycle.Kisspeptins transitive steroid feedback signals to GnRH cells, especially the positive feedback signal which causes preovulatory GnRH / LH secretion. Kisspeptins bind KISS1R in the hypothalamic GnRH neurons and evoke the release of GnRH and the onset of puberty.