ABSTRACT
To investigate the protective effect of Pentoxifylline [PTX] in carbon tetrachloride [CC1[4]] induced liver injury in adult male Wistar rat model. Experimental/Analytical study. Animal House, Isra University Hyderabad from May to December 2012. Forty five adult male Wistar rats were divided into three groups; Group A. controls received 0.9% isotonic saline, Group B. received CC1[4] orally [I.9mg/kg] mixed in olive oil, and Group C. received the PTX+ CC1[4]. Blood samples were collected for liver biochemical assays. The animals were sacrificed, liver tissue, after fixation in 4% formaldehyde, was embedded in paraffin. Tissue sections of 5micro thickness were subjected to haematoxylin and eosin staining and were assessed by light microscopy. The data was analyzed on SPSS 21.0 using one-way ANOVA, Tukey-Cramer and Chi-square tests. A p-value of