ABSTRACT
Background and aim of the work: The aim of this study is to assess the Knowledge, Attitude, and Practices [KAP] towards diabetes and its complications among physicians in Taif
Subjects and Methods: This survey was done by interviewing the physicians to fill the questionnaire focusing on their awareness about screening, diagnosis, and preventive measures of diabetic complications
Results: A total of 101 physicians [72% females], 88% of them were practicing in urban areas and 78% of them practiced > 5 years. 90% of the physicians had postgraduate qualifications and 49% of them had special training on diabetes management. Eighty one percent follow guidelines for care for diabetes. In 72% of practioners diabetic patients constituted 18-50% of patients in their daily practice and in 28% of practioners diabetic patient were > 50% of daily practice. Over 80% of the participants were aware about the correct answers. Comparing the percentages of awareness among practioners in tertiary hospitals and primary health care centers it was significantly higher in the formers [P< 0.05]. The question which had the highest percentages of correct answer was about the value of periodic examination of diabetic patient [correct in94%]. The effect of lipid profile on diabetic complications was the least to be answered correctly
Conclusion: The study revealed a good to excellent awareness of Taif practioners about early detection, diagnosis and management of diabetic complications especially those practicing in tertiary hospitals, reflecting the values of continuous medical education programs applied in such hospitals
ABSTRACT
Background and aim of the work: Laparoscopic sleeve gastrectomy [LSG] proved to be an effective operation for control of obesity and associated comorbidities. The aim of this study was to evaluate the impact of this operation on weight reduction, improvement of obesity comorbid diseases, and the quality of life [QoL]
Patients and method: A cross sectional web-based survey was conducted between June and October 2016. A total of 660 patients who was subjected to LSG volunteered in the survey and answered the online questionnaire which consisted of 30 items [multiple choice and short answered questions]
Results: the study involved 425male patients [64.4%] and 235 female patients [35.6%]. The mean preoperative BMI was significantly reduced from 38.6+/-9.1 kg/m2 to 28.4+/-6.9kg/m2 after a mean duration of 24+/-5.6 months following LSG. There was highly significant improvement [P< 0.001] in obesity comorbid diseases; however, the improvement was significant [P< 0.05] for improvement in sexual performance. The patient satisfaction from the weight reduction after LSG was rated as excellent by 68.2% of participants, as very good to good by 24.2% of participants, and as just accepted by 1.8%. 5.8% of patients had no changes or even gain weight after LSA [P>0.05]. 92.4% considered that their quality of life became better and would recommend the sleeve gastrectomy for other obese people who suffer from the obesity
Conclusion: laparoscopic sleeve gastrectomy is a good option for those with morbid obese patients as regard weight reduction, improvement of obesity comorbid diseases, and their quality of life
ABSTRACT
Background and aim of the work: Previous studies verified that Endostatin, matrix metalloproteinase [MMP] -2 and -9, in addition to tissue inhibitors of metalloproteinase [TIMP] -1 may play a crucial role in prognosis of non-small cell lung cancer [NSCLC]. In this study we will investigate the changes in the pretreatment serum levels of these factors and to evaluate their clinical implication in patients with advanced non-small cell lung cancer [NSCLC]
Patients and methods: Pretreatment serum samples were collected from 25 patients and 10 control healthy individuals. The levels of Endostatin, MMP-2, MMP-9, and TIMP-1 were measured using a sandwich enzyme immunoassay kit
Results: The pretreatment serum levels of Endostatin and TIMP1 were significantly elevated and correlated with their stages and survival [P< 0.05], where, the serum level of Endostatin in healthy subjects was 81.20 +/- 23.99 ng/ml and in patients with NSCLC was 354.40 +/- 164.01 ng/ml. The serum level of TIMP1 in healthy subjects was 1.49 +/- 0.29 ng/ml and in patients with NSCLC was 2.96 +/- 0.58 ng/ml. The serum level of MMP2 and 9 were non-significantly decreased in serum of NSCLC patients [P > 0.05], where the serum activity of MMP2 in healthy subjects was 0.14 +/- 0.03 ng/ml and in patients with NSCLC was 0.09 +/- 0.03% and the serum activity of MMP9 in healthy subjects was 0.13 +/- 0.019 ng/ml and in patients with NSCLC was 0.10 +/- 0.03%
Conclusions: Our results indicated that the circulating levels of Endostatin, and TIMP-1 in patients with NSCLC may be valuable future tools for treatment planning and monitoring of treatment, however, these blood tests need to be standardized and validated in large-scale prospective clinical trials