Effect of epidermal growth factor on adrenaline induced effects in isolated rabbit heart

Acute psychological stressors induce damage in organs as heart. Catecholamines are responsible for acute stress effects. Adrenaline, through 1-adrenergic receptors; stimulates EOF release to the blood. Because plasma catecholamine concentration is high during the stress and afterwards, organs are exposed to combined effects of both catecholamines and EGF. Intermale fighting [IF stress model] does not raise plasma creatine kinase [CK] activity ,while increases plasma transaminase and lactate dehydrogenase [LDH] activities, So the heart is protected. EGF may protect the heart against the harmful effects of epinephrine. The present research studied EGF administration on adrenaline induced effects in the rabbit heart [invitro] of 8 groups of male white New Zealand rabbits. Heart tissues were excised and incubated. revealed a significant decrease in heart rate, contractility and coronary flow rate in Epidermal growth factor gp. A non significant change in heart rate and coronary flow rate and heart contractility after infusion of alpha blocker and adrenaline.While a significant decrease in heart rate, heart contractility and coronary flow rate in either adrenaline with beta Blocker group and or EGF with adrenaline and a blocker group. EGF with adrenaline and beta Blocker group produced a significant increase in heart rate, heart contractility and coronary flow rate. In spite of EGF positive effects on heart properties, it interfered with the adrenaline positive effects through Beta receptors

Effect of telmisartan in experimentally induced diabetetes mellitfts in rats

Increased oxidative stress is involved in the pathogenesis of diabetic nephropathy and neuropathy. Angiotensin II is a know factor in the pathogenesis of diabetic complications. The protective effects of ACEIs is known in diabetic nephropathy. Thus, Angiotensin receptor antagonists may have the same role. In this study, possible antidiabetic effect of Telmisartan and its tissues antioxidant effect in [STZ] induced diabetic rats, were studied. The present study was done on 40 rats. They were divided into 2 main groups. Group I: 10 rats as control group, received distilled water. Group II: 30 rats subdivided into 3 equal subgroups as follow: Subgroup IIA: control diabetic group, received 55 mg/kg STZ intraperitoneally. Sub group IIB: diabetic rats, received 10 mg/kg telmisartan daily intragastrically. Sub group IIC: diabetic rats received 10mg/kg gliclazide daily intragastrically. Diabetes was induced by intraperitoneal injection of 55 mg/kg STZ for 8 weeks evidenced by significant increase in serum glucose, HBA[1c] and decreased Hb levels, Diabetic rats showed a significant increase in tissue TBARs and a significant decrease in tissue [GSH] and [SOD] enzymes. Telmisartan or Gliclazide in diabetic rats produced a beneficial effect on serum glucose, Hb, HBA[1c] and restored tissue GSH and SOD with a fall in tissues TBARS. Teimisartan might be proved useful in the treatment of diabetes and its complications, as Gliclazide is restricted by its secondary failure rate and side effects

Effect of Telmisartan in experimentally induced Diabetetes Mellitus in Rats

Background: Increased oxidative stress is involved in the pathogenesis of diabetic nephropathy and neuropathy. Angiotensin II is a know factor in the pathogenesis of diabetic complications. The protective effects of ACEIs is known in diabetic nephropathy. Thus, Angiotensin receptor antagonists may have the same role. In this study, possible antidiabetic effect of Telmisartan and its tissues antioxidant effect in [STZ] induced diabetic rats, were studied

Methods: The present study was done on 40 rats. They were divided into 2 main groups. Group I: 10 rats as control group, received distilled water. Group II: 30 rats subdivided into 3 equal subgroups as follow: Subgroup IIA: control diabetic group, received 55 mg/kg STZ intraperitoneally. Sub group IIB: diabetic rats, received 10 mg/kg telmisartan daily intragastrically. Sub group IIC: diabetic rats received 10mg/kg gliclazide daily intragastrically. Diabetes was induced by intraperitoneal injection of 55 mg/kg STZ for 8 weeks evidenced by significant increase in serum glucose, HBA1c and decreased Hb levels

Results: Diabetic rats showed a significant increase in tissue TBARs and a significant decrease in tissue [GSH] and [SOD] enzymes. Telmisartan or Gliclazide in diabetic rats produced a beneficial effect on serum glucose, Hb, HBA1c and restored tissue GSH and SOD with a fall in tissues TBARS

Conclusion: Telmisartan might be proved useful in the treatment of diabetes and its complications, as Gliclazide is restricted by its secondary failure rate and side effects