ABSTRACT
Our study aimed to assess the effects of using single monthly dose of intravenous cyclophosphamie administered to patients having Behcet's disease, in three doses before cataract surgery, and another three doses following the surgery. 15 Behcet's disease patients [3 females and 12 males] did phacoemulsification with intraocular lens [IOL] implantation. Cyclophosphamide was given in monthly bolus dose of 10mg/kg by iv in 1000cc normal saline over 90 minutes period. The dose was repeated for 3 months before the surgery, and another 3 months following surgery. Three cases showed mild reaction, which was controlled by single dose of IV prednisolone within 10 days. One case showed vitritis, which needed vitrectomy within the first month. Six cases showed mild hair falling. Hemorrhagic cystitis was not reported with our regimen. Leucopenia never reached less than 4000mm[2]. Cyclophosphamide is an effective and relatively safe immunosuppressive drug in short-term therapy for patients with Behcet's disease undergoing cataract surgery