ABSTRACT
The study included 22 patients of age range 12-76 years. They were selected carefully to have history of drug that induced their gastroduodenal disorders. Biopsy specimens were taken from the gastric antrum of each patient to detect Helicobacter pylori infection by the urease test. Significant association was found between Helicobacter pylori infection and drugs induced gastro duodenal disorders. As the infection was detected in 90.9% of the total patients. Treatment was given to nine H. pylori positive patients which included a single dose of amoxycillin [3gm/week] plus metronidazole [750 mg/day] for a period of two weeks. This regimen was found to be effective in eradicating H. pylori and resulted in disappearance of signs and symptoms in 83.3% of the patients who had gastroduodenal disorder triggered by drugs.