Effects of general and spinal anesthetic techniques on endothelial adhesion molecules in cesarean section / 대한마취과학회지

BACKGROUND: The aim of this study was to investigate the effects of anesthetic techniques used during general anesthesia (GA) and spinal anesthesia (SA) on endothelial adhesion molecules in the fetal circulation of healthy parturients undergoing elective cesarean section. METHODS: Patients were randomly assigned to either the general anesthesia (n = 20) or spinal anesthesia (n = 20) group. Maternal and cord blood neopterin, sE-selectin, and sL-selectin levels were measured in both groups. RESULTS: Cord blood neopterin concentrations in the SA group were not different from those in the GA group, but maternal neopterin levels in the SA group were different from those in the GA group. Maternal blood levels of sE-selectin and sL-selectin were not different between the two groups. Similarly, the cord blood levels of sE-selectin and sL-selectin were not different between the two groups. We found an increased inflammatory process in the fetal circulation depending on the anesthetic method used. CONCLUSIONS: These results indicate the effects of general and spinal anesthetic techniques on serum sL-selectin, sE-selectin, and neopterin levels in neonates and parturients undergoing elective cesarean section. sE-selectin and neopterin concentrations and leukocyte counts were higher in the fetal circulation than in the maternal circulation during both GA and SA.

Urinary methylmalonic acid in patients with acute myocardial infarction

To investigate urinary methylmalonic acid [uMMA] levels and their relationship with markers of myocyte necrosis and inflammation in patients with acute myocardial infarction [AMI]. The study participants consisted of 80 consecutive patients with AMI and 72 age- and sex-matched consecutive controls. Of the patients, 38 had ST segment elevation myocardial infarction [STEMI] and 42 had non-ST segment elevation. All patients with STEMI underwent fibrinolytic therapy. Routine laboratory tests included troponin-I, creatinine phosphokinase MB [CK-MB], high-sensitivity C-reactive protein [hs-CRP], vitamin B12, folate, homocysteine and methylmalonic acid analyses. uMMA measurements were made by a spectrophotometric method. uMMA levels were significantly higher in patients with AMI than in controls [10.1 vs. 5.2 mmol/mol creatinine, p < 0.001] and higher in patients with anterior MI compared to those with non-anterior MI [18.9 vs. 8.7 mmol/mol creatinine, p < 0.001]. In addition, uMMA levels were significantly higher in patients without successful reperfusion compared to those with successful reperfusion. In patients with STEMI, a strong positive association was found between urinary MMA and plasma hs-CRP levels [r = 0.81, p < 0.001], symptom duration [r = 0.91, p < 0.001] and wall motion score [r = 0.60, p = 0.006]. More importantly, a strong positive association was observed between uMMA and the size of myocardial infarction in patients without successful reperfusion [for CK-MB r = 0.81, p = 0.013; for wall motion score r = 0.82, p = 0.012]. uMMA levels were elevated in patients with AMI and, as such, may be a candidate biochemical indicator of larger infarct size and enhanced inflammation in patients with AMI