ABSTRACT
Objective: To assess the relation between bioimpedance measurements and metabolic parameters and C-peptide in patient with type 2 diabetes mellitus [DM]. Study Design: Cross-sectional study. Place and Duration of Study: Kartal Dr Lutfi Kirdar Training and Research Hospital, Pendik Kaynarca Diabetes Center, Exercise and Metabolism Unit, between January and March 2015
Methodology: Patients with DM, aged less than 65 years, were assessed for bioimpedance analysis, fasting plasma glucose [FPG], HbA1c, C-peptide levels, triglyceride levels, LDL-cholesterol, and HDL-cholesterol levels. Skeletal muscle index, total muscle index, skeletal muscle percentage, and total muscle percentage were used for muscle-related analyses. Mann-Whitney U-test or independent t-test were used to compare differences between two independent groups. Pearson correlation test or Spearman correlation test were used to find out correlation between variables
Results: A total of 359 DM patients were enrolled in the study. Mean age was 51.6 +/- 8.0 years, and 278 [77.7%] of the participants were females. After adjusting age and gender variables, there was no relation between muscle-related measurements and FPG, triglyceride, LDL-cholesterol [p>0.05]. However, there was muscle-related indexes [MRI] positively correlation with C-peptide and inversely associated with HDL-cholesterol [p<0.05]
Conclusion: Muscle-related indices positively correlated with C-peptide, which showed endogenous insulin reserve