ABSTRACT
Thirty four non-pregnant females between the ages of 23 and 45 years with a mean of 31.03 years and suffering from vaginal candidiasis were included in this study. The diagnosis was confirmed both clinically and mycologically by microscopy and culture. All patients received one capsule of Fluconazole 150mg orally and were seen 7-14 days after therapy as well as 30-45 days post-treatment. Complete cure with disappearance of all pretreatment signs and symptoms occurred in 30 patients [88 percent] while improvement occurred in 4 patients [12 percent]. Mycological cure with complete eradication of Candida was achieved in 31 patients [91 percent] while persistence was reported in 3 patients [9 percent]. No relapses were reported till the last follow up visit [day 30-45]. No statistically significant change in the mean values for blood picture, liver and renal function tests after therapy when compared to pretreatment figures. No adverse effects were reported in any of the included cases. This study concludes that oral Fluconazole in a single 150mg capsule is effective, safe and well tolerated for the treatment of vaginal candidiasis