ABSTRACT
Dermatoglyphic pattern was studied in 39 cases of idiopathic epilepsy, 20 parents known to have children with idiopathic epilepsy and 30 normal sibs of epileptic children. A control group which included 30 healthy age and sex-matched children, 25 sibs and 20 parents [10 husbands and their wives] was also studied. Our results revealed increased main line index especially on right palm, decreased total ridge count in right and left palms and more frequent existence of transverse line epileptic children as compared to their controls. No similar significant differences were found between the parents and sibs of epileptic children and their controls except for the increased main line index which was significantly increased in parents of epileptic children [P less than 0.05]. This emphasizes the existence of genetic predisposition idiopathic epilepsy
Subject(s)
DermatoglyphicsABSTRACT
In this work the mode of inheritance of idiopathic epilepsy was studied in an Egyptian population in a trial to define the role of environmental and genetic factors in this disorder. Members from 32 families were studied. These included 39 cases of idiopathic epilepsy, 20 parents having children with idiopathic epilepsy. 30 normal sibs of epileptic children and 3 dizygotic twins encountered in the above families, 2 of them were normal while the third twin compared an epileptic male and a normal female. A control group including 30 healthy age and sex-matched children, 25 sibs and 20 parents were also studied. Cases and controls subjected to full history talking, thorough clinical assessment, plain X-ray skull, and E.E.G. recording. Genetic analysis included pedigree construction, segregation and consanguinity analysis, besides blood grouping and twin studied. Idiopathic epilepsy has been shown to fit a multifactor mode of inheritance. This involves interaction of both genetic and environmental factors. E.E.G. Patterns are transferred on an autonomic dominants gene with grouping revealed no significant differences between patients, their parents and sibs compared to their controls