ABSTRACT
Uric acid is the metabolic product of purine metabolism in human. Excess serum accumulation of uric acid can lead to a type of arthritis known as gout. Elevated serum uric acid [hyperuricemia] can result from high intake of purine-rich foods, high fructose intake [regardless of fructose's low Glycemic Index [GI] value] and/or impaired excretion by the kidneys. Saturation levels of uric acid in blood may result in one form of kidney stones when the urate crystalizes in the kidney. Aim of work: This study was carried out to investigate the effect of dietary intervention of different concentrations [5% and10%] from parsley [seeds and leaves], strawberries and tomato on hyperuricemia in rats. This study was carried out on 80 male albino rats; sprague-dawley strain weighing [130 +/- 10 gm] were housed in well aerated wire cages. All animals were kept under normal healthy conditions and fed on basal diet for one week for adaptation. After the adaptation period, rats were divided into 10 groups [8 rats/group].Rats were housed individually in wire cages and all groups were similar for total body weight. Group [A] [Normal control]; fed standard diet only. Group B [Positive control]: fed high fructose diet. Two Groups[C]: fed high fructose diet + parsley seeds, S and10%.Two Group D: fed high fructose diet + parsley leaves, 5and10%.Two Groups E: fed high fructose diet + 5 and10% strawberries. Two Groups [F]: fed high .fructose diet + 5 and 10% tomato for diet. The experimental period was 6 weeks. The results showed significant decrease [P<0.05] in serum uric acid and urea nitrogen u compared to positive control [+ve] and also significant decrease [P<0.05] in scrum total cholesterol, triglycerides, VLDL-C compared to control positive group. The best results of histological examination of liver were in rats group treated with 5%and10% Strawberry followed by Parsley seeds and leaves 10%. While the best histological examinations of kidney were observed in parsley seeds and leaves 10% followed by 5%.Conclusion: It could be concluded that parsley [leave-1 and seeds], tomato and strawberry reduce serum uric acid and urea nitrogen levels and improve kidney and liver functions and also reduce the histological changes of liver and kidney
ABSTRACT
It has been reported that fish oil and Vitamin E consumption associated with a reduction in cardiovascular disease. The present study evaluates the effect of fish oil's supplementation with or without vitamin E in restricting oxidative stresses in hypercholesterolemic rats. Fifty six adult male Sprague-Dawley strain weighing [100-120g] divided into 7 groups [8 rats / group]. First and second groups, served as negative and positive controls, fed on basal and atherogenic diet respectively. While the other fr1e groups fed on atherogenic diet with adding 200 mg a-tocopherol acetate, 3% fish oil, 3% fish oil+ 200 mg a-tocopherol acetate, 5% fish oil and 5% fish oil + 200 mg a-tocopherol acetate respectively for eight weeks. Results revealed that there were highly significant decrement in body weight gain, food intake and feed efficiency in groups fed on fish oil + vit E, also revealed that the clotting time of blood showed no significant change in all treated groups as with negative and positive control groups except in group fed 5% FO there was a significant increase as compared with positive control. Also feeding hypercholesterolemic diet with fish oil treatment caused increment in plasma lipid peroxidation and reduction in enzymatic antioxidants [GSH and SOD], while supplementations with vitamin E to hypercholesterolemic diet and fish oil reduced lipid peroxidation and increased antioxidant activities
ABSTRACT
The present study evaluates the effect of some dietary animal and plant protein on the hp1d profile m experimental animals'. Sixty· four adult male albino rats of Sprague Dawely strain weighing [160+/- 8.4 g] were divided into eight groups every group contain 8 rats. The first group served as negative control, fed on standard diet. The second group served as positive control, fed on hyperlipidemic diet contain 10% level casein. Moreover, the remaining 6 groups fed on hyperlipidemic diet at 10%, level of, protein obtained from the following protein sources: whey; soy; meat; [meat protein + whey protein, 1:1]; [meat protein+ soy protein, 1:1] and [meat protein+ soy protein +Whey protein, 1: 1: 1 ]. The result revealed that serum total lipids of all groups were significantly lowered [P:S 0.01] except group fed on meat, serum Total cholesterol; triglycerides; low density lipoprotein [LDL-C] and high density lipoprotein cholesterol [HDL-C] of all groups were significantly reduced [P:S 0.01] as compared with positive control group. Fecal excretion of neutral steroids of all groups were significantly elevated [P: S 0.01] except the group fed on mixture of [meat protein+ soy protein +Whey protein] as compared with positive control group