Prenatal Development of the cochlear nuclei in albino rat

In this work, prenatal cellular differentiation of the CN in relation to the central fibres of the cochlear nerve was studied in albino rat embryos. Specimensfrom rat embryos were taken daily from the 12th embryonic day to tull term. It was studied by cresy fast violet and Cajal's reduced silver stains. The central fibers of the cochlear nerve were found to reach the brain stem before the 15th embryonic day, which is the age of appearance of the primordium of the CN. Cellular differentiation of the CN started from the 18th day and at full term the cells of the VCN were more differentiated than those of the DCN. The variations in the age of appearance of the CN and in the degree of its cellular differentiation may be related to the animal species, the stage of cochlear development and the neonatal behaviour of different animals

Ultrastructural changes in the hepatocytes of albino rats treated with high doses of rifampin

Twelve rats were used, of which 6 rats received 400 mg/kg rifampicin daily for 5 days through an intragastric route, 3 rats received equivalent amounts of saline daily for 5 days, and 3 rats received nothing. The animals were sacrificed on the 6th day after initiation of treatment. Hepatic tissues were taken from all animals and were processed for electron microscopic study. In EM study. there was reduction of glycogen content in all centrilobular hepatocytes, in which few discrete glycogen particles appeared in relation to SER. The periportal hepatocytes showed heterogeneous response in which some cells kept high levels of glycogen and other cells showed marked reduction in glycogen content. There was mild proliferation of SER in both periportal and centrilobular hepatocytes while RER was increased in both areas. Intimate relation between RER and mitochondia was explained