ABSTRACT
Parkinson disease is one of the most prevalent degenerative nervous system diseases. Some recent studies show the possible effects of uric acid on this disorder. The aim of this study was to evaluate serum level of uric acid in patients with Parkinson disease. Serum uric acid were determined in 50 patients with Parkinson's disease and compared with 50 healthy persons, which were matched with age and sex. Data were analyzed with software SPSS-16 and statistical descriptive methods [mean-percentage, SD] and t-test. In this study, 26 men [52%] and 24 women [48%] were evaluated. The mean serum uric acid in patients was 4.79 +/- 1.21 and in the control group was 5.85 +/- 1.41. This difference was statistically significant [p
ABSTRACT
Management of postoperative bleeding in patients receiving warafin, has always been one of the most challenges for dentists. Cessation in using warafin 2-3 days before tooth extraction is one of the methods for preventing bleeding in these patients, but it may increase the risk of thromboembolism. The aim of this study was to use localized haemostatic drugs instead including gelatin sponge and tranexamic acid mouthwash. In this clinical trial study, 22 patients who were currently receiving warafin with INR range of 2-4 were selected. For each patient 3 teeth were extracted in several times. After extraction of each tooth, Gelatin sponge, Tranexamic acid 4.8% mouth wash and sterile gauze [without any haemostatic drug] were used. Tendency of bleeding in 66 teeth, 2 and 24 hours after extraction was checked. No suture was used for any patient. Data were analyzed with descriptive statistics [frequency and average] and Chi-square and Fisher's exact tests. Rate of bleeding in three groups were measured: Gelatin sponge: 9.1%, Tranexamic acid 4.8% mouthwash: zero and sterile gauze [without any haemostatic drug]: 27.3%. In patients treated with warafin, interruption in use of warfarin for tooth extraction is not needed. Local haemostasis with tranexamic acid, gelatin sponge, INR