ABSTRACT
Background and Aim: Spinal cord injury [SCI] is one of the worst kinds of traumatic injuries with remarkable social and economic effects on communities
Methods and Materials/Patients: In this prospective randomized clinical trial, 122 patients with traumatic spinal cord injury were admitted to Poursina hospital within 48 hours of injury to compare granulocyte colony stimulating factor [G-CSF] and high-dose methylprednisolone as neuroprotective therapy
Results: In this research, 122 patients were studied out of whom 62 patients were included in the granulociote colony-stimulating factor [G-CSF] group with a mean age of 40.4, and 60 patients in the methylprednisolone group with an average age of 40.10 years. 55 out of 122 patients [45%] were completely paralyzed [Grade AIS:A] and 67 [55%] were with incomplete spinal injury [Grade AIS:B,C,D]. The average American spinal injury association [ASIA] sensory scores in the two groups were similarly compared in the same four time intervals, and p values were 0.7, 0.3, 0.2, and 0.1. They were not statistically significant
Conclusion: According to the results, the G-CSF was shown to be beneficial in average ASIA motor and sensory scores in the two groups of male patients at six months of onset of G-CSF treatment [p value=0.04], and average ASIA motor scores improvement in the falls subgroup patients also differed significantly within six months of onset of G-CSF treatment [p value=0.03]. A multicentre prospective randomized clinical trial to compare the placebo effect with G-CSF protocol's treatment, and also assessment of the cost benefits of the common medical treatment versus G-CSF are needed
ABSTRACT
Background and Importance: Hydatid disease of the spine is rare but constitutes approximately 50% of bone involvement cases in human hydatidosis. It is a severe condition associated with a high rate of morbidity, disability and mortality
Case Presentation: In the present paper, we report an intriguing case of cervical spinal hydatid disease mimicking traumatic burst fracture
Conclusion: A high degree of suspicion combined with good-quality neuroimaging is important for early and correct diagnosis. Because of the location and the potential for progression, spinal hydatid disease surgical treatment is the mainstay of treatment
ABSTRACT
Background and Aim: the purpose of this study was to evaluate and compare the pain of patients with spondylolisthesis who had undergone either of the surgery techniques: posterolateral fusion [PLF] or posterior lumbar interbody fusion [PLIF]
Methods and Materials/Patients: in a prospective observational study, 102 surgical candidates with low grade degenerative and isthmic spondylolisthesis were enrolled from 2012 to 2014. The observed patients were into two groups: PLF and PLIF. Assessing of pain has been done by a questionnaire using Visual Analogue Scale [VAS] scores. The questionnaire was completed by all patients before surgery, the day after surgery, after six months and after one year
Results: there were no statistically significant differences in terms of age and sex distribution, type of spondylolisthesis and pre-operation pain between groups [p>0.05]. Comparison of the mean VAS scores of two groups over the whole study period showed a significant statistical difference [p-value<0.05], although comparison of VAS at three points in time showed a mixed result. VAS scores showed no significant differences between two groups before surgery, the day after surgery and one year after surgery [p>0.05], but the difference of mean VAS scores between groups 6 months after surgery was statistically significant [p<0.05]. Analyzing the course of VAS scores over the study period showed a descending pattern for either of the groups [p<0.0001]
Conclusion: both surgical fusion techniques [PLF and PLIF] showed to be effective in treating low grade degenerative and isthmic spondylolisthesis, but PLIF was related to better outcome with respect to pain control
ABSTRACT
Background and Aim: glioblastoma multiforme [GBM], the highest grade glioma [grade IV], is the most malignant form of astrocytoma in adults. This study aimed at evaluating the relationship between demographic, clinical and medical factors with GBM outcome
Methods and Materials/Patients: through a cross-sectional design, 58 patients with newly diagnosed GBM were studied from 1999 to 2015 in Guilan province [North of Iran]. Demographic, clinical and medical data including age, gender, score of Karnofsky Performance Scale [KPS], status at discharge, extent of resection [EOR] and administration of post-operative radio-chemotherapy were recorded in an individual questionnaire. The data were analyzed using chi-square and fisher exact tests
Results: of all patients, 35 [60.3%] cases were men and 23 [39.7%] were women. Age range [at the time of diagnosis of GBM] was 18-82 years [54.86+/-16.34]. The most common side and location of tumor were left hemisphere and frontal lobe, respectively. 41 patients [70.7%] received total surgical resection. Half of patients were treated with simultaneous post-operative radiation therapy and chemotherapy.11 [19%] of all cases died. About 41 [70.6%] of patients demonstrated KPS 50-70
Conclusion: GBM is a frequent malignant brain tumor with male predominance and high occurrence in age range of ?50 years. The number of dead patients increases with decreased KPS. Total surgical resection followed by concomitant radiation therapy and chemotherapy were common standard therapeutic regimens